Orofacial clefts (OFCs) rank as the second most common congenital birth defect in the
United States after Down syndrome and are the most common head and neck congenital …

With an average worldwide prevalence of approximately 1.2/1000 live births, orofacial clefts
are the most common craniofacial birth defects in humans. Like other complex disorders …

Inter-individual variation in facial shape is one of the most noticeable phenotypes in
humans, and it is clearly under genetic regulation; however, almost nothing is known about …

Heterozygous mutations in the transcription factor gene p63 are causative for several
syndromes, with ectodermal dysplasia, orofacial clefting and limb malformations as the key …

Compared with the embryonic development of other organs, development of the secondary
palate is seemingly simple. However, each step of palatogenesis, from initiation until …

Orofacial clefts (OFCs)—primarily cleft lip and cleft palate—are among the most common
birth defects in all populations worldwide, and have notable population, ethnicity, and …

Orofacial clefts are the most common craniofacial birth defects and one of the most common
congenital malformations in humans. They require complex multidisciplinary treatment and …

Although genome-wide association studies (GWASs) for nonsyndromic orofacial clefts have
identified multiple strongly associated regions, the causal variants are unknown. To address …

Cleft lip and/or cleft palate (CL/P) collectively are well known as being amongst the most
common birth defects but we still have difficulty explaining why the majority of cases occur …

Non syndromic orofacial clefts specifically non-syndromic cleft lip/palate are one of the most
common craniofacial malformation among birth defects in human having multifactorial …