How viral genetic variants and genotypes influence disease and treatment outcome of chronic hepatitis B. Time for an individualised approach?
Chronic hepatitis B virus (HBV) infection remains a global problem. Several HBV genotypes
exist with different biology and geographical prevalence. Whilst the future aim of HBV …
exist with different biology and geographical prevalence. Whilst the future aim of HBV …
Puzzles, challenges, and information reservoir of SARS-CoV-2 quasispecies
E Domingo, B Martínez-González… - Journal of …, 2023 - Am Soc Microbiol
Upon the emergence of SARS-CoV-2 in the human population, it was conjectured that for
this coronavirus the dynamic intra-host heterogeneity typical of RNA viruses would be toned …
this coronavirus the dynamic intra-host heterogeneity typical of RNA viruses would be toned …
Evidence of severe acute respiratory syndrome coronavirus 2 reinfection after recovery from mild coronavirus disease 2019
JS Lee, SY Kim, TS Kim, KH Hong… - Clinical Infectious …, 2021 - academic.oup.com
Background Positive results from real-time reverse-transcription polymerase chain reaction
(rRT-PCR) in recovered patients raise concern that patients who recover from coronavirus …
(rRT-PCR) in recovered patients raise concern that patients who recover from coronavirus …
Within-host genetic diversity of SARS-CoV-2 lineages in unvaccinated and vaccinated individuals
Viral and host factors can shape SARS-CoV-2 evolution. However, little is known about
lineage-specific and vaccination-specific mutations that occur within individuals. Here, we …
lineage-specific and vaccination-specific mutations that occur within individuals. Here, we …
Successive annual influenza vaccination induces a recurrent oligoclonotypic memory response in circulating T follicular helper cells
T follicular helper (TFH) CD4 cells are crucial providers of B cell help during adaptive
immune responses. A circulating population of CD4 T cells, termed cTFH, have similarity to …
immune responses. A circulating population of CD4 T cells, termed cTFH, have similarity to …
[HTML][HTML] Insights from deep sequencing of the HBV genome—unique, tiny, and misunderstood
Hepatitis B virus (HBV) is a unique, tiny, partially double-stranded, reverse-transcribing DNA
virus with proteins encoded by multiple overlapping reading frames. The substitution rate is …
virus with proteins encoded by multiple overlapping reading frames. The substitution rate is …
RNA-catalyzed evolution of catalytic RNA
N Papastavrou, DP Horning… - Proceedings of the …, 2024 - National Acad Sciences
An RNA polymerase ribozyme that was obtained by directed evolution can propagate a
functional RNA through repeated rounds of replication and selection, thereby enabling …
functional RNA through repeated rounds of replication and selection, thereby enabling …
Influenza A virus undergoes compartmentalized replication in vivo dominated by stochastic bottlenecks
Transmission of influenza A viruses (IAV) between hosts is subject to numerous physical
and biological barriers that impose genetic bottlenecks, constraining viral diversity and …
and biological barriers that impose genetic bottlenecks, constraining viral diversity and …
Lethal mutagenesis of hepatitis C virus induced by favipiravir
Lethal mutagenesis is an antiviral approach that consists in extinguishing a virus by an
excess of mutations acquired during replication in the presence of a mutagen. Here we …
excess of mutations acquired during replication in the presence of a mutagen. Here we …
[HTML][HTML] Intact proviruses are enriched in the colon and associated with PD-1+ TIGIT− mucosal CD4+ T cells of people with HIV-1 on antiretroviral therapy
C Vellas, M Nayrac, N Collercandy, M Requena… - …, 2024 - thelancet.com
Background The persistence of intact replication-competent HIV-1 proviruses is responsible
for the virological rebound off treatment. The gut could be a major reservoir of HIV-1 due to …
for the virological rebound off treatment. The gut could be a major reservoir of HIV-1 due to …