Phosphoinositides (PI) form just a minor portion of the total phospholipid content in cells but
are significantly involved in cancer development and progression. In several cancer types …

G protein-coupled receptors (GPCRs) are cell membrane receptors for various ligands.
Recent studies have suggested that GPCRs transmit animal steroid hormone signals …

ABSTRACT CTSD/CathD/CATD (cathepsin D) is a lysosomal aspartic protease. A
distinguishing characteristic of CTSD is its dual functions of promoting cell proliferation via …

Holometabolous insects stop feeding at the final larval instar stage and then undergo
metamorphosis; however, the mechanism is unclear. In the present study, using the serious …

Juvenile hormone (JH) is a key regulator of a wide diversity of developmental and
physiological events in insects. Although the intracellular JH receptor methoprene-tolerant …

The encapsulation reaction in invertebrates is analogous to granuloma formation in
vertebrates, and this reaction is severely compromised when ecdysone signaling is blocked …

The endoplasmic reticulum (EnR) stress sensor, the unfolded protein response (UPR), plays
a key role in regulating intracellular protein homeostasis. The extensively studied reactive …

Autophagy regulates cell survival (or cell death in several cases), whereas apoptosis
regulates cell death. However, the relationship between autophagy and apoptosis and the …

Juvenile hormone (JH) controls many biological events in insects by triggering dramatic
changes in gene expression in target cells. The Methoprene-tolerant (MET) protein, an …

The nuclear receptor EcRB1, which is activated by the insect steroid hormone 20-
hydroxyecdysone (20E), is reportedly phosphorylated by a protein kinase after 20E …