Amide bonds occur in over half of target compounds in medicinal chemistry patents, making
amide bond formation the most commonly performed reaction in the pharmaceutical …

Enzyme catalysis is gaining increasing importance in synthetic chemistry. Nowadays, the
growing number of biocatalysts accessible by means of bioinformatics and enzyme …

Marine macroalgae biomass is often used for the production of ingredients in cosmetics.
These ingredients can have one of the three main functions:(1) they are considered as …

Heterocycles are a privileged motif that appears as a momentous objective in medicinal
chemistry. An important class of compounds for drug discovery and design is indole and its …

The synthesis of the amide bond between an amine and a carboxylic acid is one of the most
significant reactions in industrial pharmaceutical synthesis. Despite the apparent simplicity …

Highlights•Amino acid producers improved combining classical mutagenesis with metabolite
sensors.•New route to efficient l-proline production established.•C. glutamicum engineered …

Amides are widespread in biologically active compounds with a broad range of applications
in biotechnology, agriculture and medicine. Therefore, as alternative to chemical synthesis …

The ability to site-selectively modify equivalent functional groups in a molecule has the
potential to streamline syntheses and increase product yields by lowering step counts …

The amide functional group is ubiquitous in nature and one of the most important motifs in
pharmaceuticals, agrochemicals, and other valuable products. While coupling amides and …

Phosphonate natural products, with their potent inhibitory activity, have found widespread
use across multiple industries. Their success has inspired development of genome mining …