Nitric oxide: physiological functions, delivery, and biomedical applications
Nitric oxide (NO) is a gaseous molecule that has a central role in signaling pathways
involved in numerous physiological processes (eg, vasodilation, neurotransmission …
involved in numerous physiological processes (eg, vasodilation, neurotransmission …
Nitric oxide signalling in cardiovascular health and disease
C Farah, LYM Michel, JL Balligand - Nature Reviews Cardiology, 2018 - nature.com
Nitric oxide (NO) signalling has pleiotropic roles in biology and a crucial function in
cardiovascular homeostasis. Tremendous knowledge has been accumulated on the …
cardiovascular homeostasis. Tremendous knowledge has been accumulated on the …
Treatments targeting inotropy: a position paper of the Committees on Translational Research and Acute Heart Failure of the Heart Failure Association of the European …
Acute heart failure (HF) and in particular, cardiogenic shock are associated with high
morbidity and mortality. A therapeutic dilemma is that the use of positive inotropic agents …
morbidity and mortality. A therapeutic dilemma is that the use of positive inotropic agents …
β3AR-dependent brain-derived neurotrophic factor (BDNF) generation limits chronic postischemic heart failure
Background: Loss of brain-derived neurotrophic factor (BDNF)/TrkB (tropomyosin kinase
receptor B) signaling accounts for brain and cardiac disorders. In neurons, β-adrenergic …
receptor B) signaling accounts for brain and cardiac disorders. In neurons, β-adrenergic …
The beta3 adrenergic receptor in healthy and pathological cardiovascular tissues
LYM Michel, C Farah, JL Balligand - Cells, 2020 - mdpi.com
The third isotype of beta-adrenoreceptors (β3-AR) has recently come (back) into focus after
the observation of its expression in white and beige human adipocytes and its implication in …
the observation of its expression in white and beige human adipocytes and its implication in …
Interaction of the Joining Region in Junctophilin-2 With the L-Type Ca2+ Channel Is Pivotal for Cardiac Dyad Assembly and Intracellular Ca2+ Dynamics
Rationale: Ca2+-induced Ca2+ release (CICR) in normal hearts requires close
approximation of L-type calcium channels (LTCCs) within the transverse tubules (T-tubules) …
approximation of L-type calcium channels (LTCCs) within the transverse tubules (T-tubules) …
Novel sGC stimulators and sGC activators for the treatment of heart failure
S Breitenstein, L Roessig, P Sandner, KS Lewis - Heart failure, 2017 - Springer
The burden of heart failure (HF) increases worldwide with an aging population, and there is
a high unmet medical need in both, heart failure with reduced ejection fraction (HFrEF) and …
a high unmet medical need in both, heart failure with reduced ejection fraction (HFrEF) and …
Targeting β3-adrenergic receptors in the heart: selective agonism and β-blockade
Cardiac diseases, such as heart failure, remain leading causes of morbidity and mortality
worldwide, with myocardial infarction as the most common etiology. HF is characterized by β …
worldwide, with myocardial infarction as the most common etiology. HF is characterized by β …
Cardiac salvage by tweaking with beta-3-adrenergic receptors
JL Balligand - Cardiovascular research, 2016 - academic.oup.com
Overstimulation of the orthosympathetic system leads to cardiovascular cell and tissue
damage through prolonged activation of β-1-2 adrenergic receptors (BARs). The more …
damage through prolonged activation of β-1-2 adrenergic receptors (BARs). The more …
Sex differences in cardiovascular diseases: a matter of estrogens, ceramides, and sphingosine 1-phosphate
The medical community recognizes sex-related differences in pathophysiology and
cardiovascular disease outcomes (CVD), culminating with heart failure. In general, pre …
cardiovascular disease outcomes (CVD), culminating with heart failure. In general, pre …