[HTML][HTML] Macrophages in health and disease
The heterogeneity of tissue macrophages, in health and in disease, has become
increasingly transparent over the last decade. But with the plethora of data comes a natural …
increasingly transparent over the last decade. But with the plethora of data comes a natural …
Tissue-specific macrophages: how they develop and choreograph tissue biology
Macrophages are innate immune cells that form a 3D network in all our tissues, where they
phagocytose dying cells and cell debris, immune complexes, bacteria and other waste …
phagocytose dying cells and cell debris, immune complexes, bacteria and other waste …
Hepatic inflammatory responses in liver fibrosis
L Hammerich, F Tacke - Nature Reviews Gastroenterology & …, 2023 - nature.com
Chronic liver diseases such as nonalcoholic fatty liver disease (NAFLD) or viral hepatitis are
characterized by persistent inflammation and subsequent liver fibrosis. Liver fibrosis critically …
characterized by persistent inflammation and subsequent liver fibrosis. Liver fibrosis critically …
Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease–novel insights into cellular communication circuits
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease and is
emerging as the leading cause of cirrhosis, liver transplantation and hepatocellular …
emerging as the leading cause of cirrhosis, liver transplantation and hepatocellular …
[HTML][HTML] Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches
M Guilliams, J Bonnardel, B Haest, B Vanderborght… - Cell, 2022 - cell.com
The liver is the largest solid organ in the body, yet it remains incompletely characterized.
Here we present a spatial proteogenomic atlas of the healthy and obese human and murine …
Here we present a spatial proteogenomic atlas of the healthy and obese human and murine …
Liver macrophages in health and disease
M Guilliams, CL Scott - Immunity, 2022 - cell.com
Single-cell and spatial transcriptomic technologies have revealed an underappreciated
heterogeneity of liver macrophages. This has led us to rethink the involvement of …
heterogeneity of liver macrophages. This has led us to rethink the involvement of …
An integrated view of anti-inflammatory and antifibrotic targets for the treatment of NASH
Successful development of treatments for non-alcoholic fatty liver disease and its
progressive form, non-alcoholic steatohepatitis (NASH), has been challenging. Because …
progressive form, non-alcoholic steatohepatitis (NASH), has been challenging. Because …
Macrophage functional diversity in NAFLD—more than inflammation
Macrophages have diverse phenotypes and functions due to differences in their origin,
location and pathophysiological context. Although their main role in the liver has been …
location and pathophysiological context. Although their main role in the liver has been …
Roles of macrophages in tumor development: a spatiotemporal perspective
Macrophages are critical regulators of tissue homeostasis but are also abundant in the
tumor microenvironment (TME). In both primary tumors and metastases, such tumor …
tumor microenvironment (TME). In both primary tumors and metastases, such tumor …
[HTML][HTML] Identification of a Kupffer cell subset capable of reverting the T cell dysfunction induced by hepatocellular priming
Kupffer cells (KCs) are highly abundant, intravascular, liver-resident macrophages known for
their scavenger and phagocytic functions. KCs can also present antigens to CD8+ T cells …
their scavenger and phagocytic functions. KCs can also present antigens to CD8+ T cells …