The neurovascular unit (NVU) is composed of vascular cells, glial cells, and neurons. As a
fundamental functional module in the central nervous system, the NVU maintains …

Parkinson's disease is one of the most common neurodegenerative diseases in the elderly.
The motor symptoms occur predominantly due to substantial dopamine depletion, caused by …

Background The majority of those infected by ancestral Severe Acute Respiratory Syndrome
Coronavirus 2 (SARS-CoV-2) during the UK first wave (starting March 2020) did not require …

Parkinson's disease (PD) is a neurodegenerative disease that is generally thought to be
caused by multiple factors, including environmental and genetic factors. Emerging evidence …

Alpha-synuclein (aSyn) accumulates in intracellular inclusions in synucleinopathies, but the
molecular mechanisms leading to disease are unclear. We identify the 10 kDa heat shock …

S100B is a calcium-binding protein mainly expressed by astrocytes, but also localized in
other definite neural and extra-neural cell types. While its presence in biological fluids is …

Pro-inflammatory and amyloidogenic S100A9 protein is an important contributor to
Alzheimer's disease (AD) pathology. Traumatic brain injury (TBI) is viewed as a precursor …

Mutations in glucocerebrosidase cause the lysosomal storage disorder Gaucher's disease
and are the most common risk factor for Parkinson's disease. Therapies to restore the …

Parkinson's disease (PD), the second most common neurodegenerative disorder, is
characterized by neuroinflammation, formation of Lewy bodies, and progressive loss of …

Parkinson's disease (PD) is a common neurodegenerative disease in the middle-aged and
elderly populations. The purpose of this study was to investigate the clinical value of lncRNA …