The Bcl-2 family consists of about 20 homologues of important pro-and anti-apoptotic
regulators of programmed cell death. The established mode of function of the individual …

One of the major cancer types that have gained significant importance globally is the breast
cancer due to its socio-economic impact. Breast cancer research is an area of considerable …

Bcl-x S, a proapoptotic member of the Bcl-2 protein family, is localized in the mitochondria
and induces apoptosis in a caspase-and BH3-dependent manner by a mechanism involving …

Pulmonary hypertension is characterized by thickened pulmonary arterial walls due to
increased number of pulmonary artery smooth muscle cells (PASMC). Apoptosis of PASMC …

The mechanism of action of pro-apoptotic proteins is difficult to study in vivo because of their
death effect, which makes it problematic to obtain sufficient homogeneous experimental …

Rocaglaol is a cytotoxic cyclopenta [b] benzofuran isolated from the bark of Aglaia
crassinervia. It exhibited in vitro cytotoxic activity against Lu1, LNCaP and MCF-7 cells with …

Programmed cell death and survival are controlled by complex pathways, with the anti-
apoptotic proteins Bcl-2 and Bcl-XL and the pro-apoptotic proteins Bax and Bcl-XS being …

To examine the effect of the bcl-xs gene on the sequence from hepatic precancerous
lesions, foci and neoplastic nodules, to hepatocellular carcinomas, Sprague–Dawley rats …

Bcl-xS, a pro-apoptotic member of the Bcl-2 protein family, is localized in the mitochondrial
outer membrane and induces caspase-dependent and nerve growth factor (NGF)-inhibitable …

Objectives: To determine whether a Bcl-xS adenoviral vector has therapeutic potential in an
ascites model of human breast cancerin nude mice. Methods: Advanced ascites were …