The hypermobile type of Ehlers–Danlos syndrome (hEDS) is likely the most common
hereditary disorder of connective tissue. It has been described largely in those with …

Objective Women have a higher prevalence of osteoarthritis (OA) and worse clinical courses
than men. However, the underlying factors and therapeutic outcomes of these sex-specific …

Osteoarthritis (OA) is a highly prevalent joint disease that primarily affects about 10% of the
world's population over 60 years old. The purpose of this study is to systematically review …

Objectives Epidemiological and experimental studies have established obesity to be an
important risk factor for osteoarthritis (OA), however, the mechanisms underlying this link …

Background Osteoarthritis (OA) is a slowly developing and debilitating disease, and there
are no validated specific biomarkers for its early detection. To improve therapeutic …

Osteoarthritis (OA) of joints such as the knee and hip are very prevalent, and the number of
individuals affected is expected to continue to rise. Currently, conservative treatments after …

This review article is a compendium of six individual manuscripts, a Commentary, and an
Executive Summary. This body of work is entitled “The Impact of Sex and Gender on …

Objective To investigate the longitudinal association between endogenous sex hormones
and knee osteoarthritis (OA) structures and pain. Method We examined 200 participants …

This review focuses on the question of metabolic syndrome (MS) being a complex, but
essentially monophyletic, galaxy of associated diseases/disorders, or just a syndrome of …

Osteoarthritis (OA) is one of the most common degenerative diseases of articular cartilage.
During OA, all the elements that contribute to the joint undergo physiological and structural …