Rituximab for the treatment of multiple sclerosis: a review

CG Chisari, E Sgarlata, S Arena, S Toscano, M Luca… - Journal of …, 2022 - Springer
In the last decades, evidence suggesting the direct or indirect involvement of B cells on
multiple sclerosis (MS) pathogenesis has accumulated. The increased amount of data on …

Targeting B cells and plasma cells in autoimmune diseases: From established treatments to novel therapeutic approaches

A Merino‐Vico, G Frazzei… - European journal of …, 2023 - Wiley Online Library
Autoimmune diseases are characterized by the recognition of self‐antigens by the immune
system, which leads to inflammation and tissue damage. B cells are directly and indirectly …

Impaired humoral responses to COVID-19 vaccination in patients with lymphoma receiving B-cell–directed therapies

P Ghione, JJ Gu, K Attwood, P Torka… - Blood, The Journal …, 2021 - ashpublications.org
Following a similar report on multiple myeloma, Ghione and colleagues report the expected
observation that patients with non-Hodgkin lymphoma (NHL) receiving anti-B cell therapies …

[HTML][HTML] Major role of IgM in the neutralizing activity of convalescent plasma against SARS-CoV-2

R Gasser, M Cloutier, J Prévost, C Fink, É Ducas… - Cell reports, 2021 - cell.com
Characterization of the humoral response to SARS-CoV-2, the etiological agent of COVID-
19, is essential to help control the infection. The neutralization activity of plasma from …

Human or chimeric monoclonal anti-CD20 antibodies for children with nephrotic syndrome: a superiority randomized trial

P Ravani, M Colucci, M Bruschi… - Journal of the …, 2021 - journals.lww.com
Background The chimeric anti-CD20 monoclonal antibody rituximab is effective in steroid-
dependent and calcineurin inhibitor–dependent forms of nephrotic syndrome, but many …

Safety of newer disease modifying therapies in multiple sclerosis

G Jalkh, R Abi Nahed, G Macaron, M Rensel - Vaccines, 2020 - mdpi.com
In the past decade, the therapeutic arsenal for multiple sclerosis has expanded greatly.
Newer more potent disease modifying therapies (DMTs) with varying mechanisms of actions …

Obinutuzumab in frequently relapsing and steroid-dependent nephrotic syndrome in children

C Dossier, S Bonneric, V Baudouin… - Clinical Journal of the …, 2023 - journals.lww.com
Background B-cell depletion with rituximab induces sustained remission in children with
steroid-dependent or frequently relapsing nephrotic syndrome. However, most patients …

[HTML][HTML] Anti-CD20 antibody therapy and risk of infection in patients with demyelinating diseases

NR Oksbjerg, SD Nielsen, M Blinkenberg… - Multiple Sclerosis and …, 2021 - Elsevier
Background Anti-CD20 antibody therapy may be associated with an increased risk of
infections. We therefore investigated risk factors for infection in patients with demyelinating …

Update on the application of monoclonal antibody therapy in primary membranous nephropathy

L Deng, G Xu - Drugs, 2023 - Springer
When first introduced, rituximab (RTX), a chimeric anti-CD20 monoclonal antibody, brought
about an alternative therapeutic paradigm for primary membranous nephropathy (PMN) …

Rituximab-induced hypogammaglobulinemia and infection risk in pediatric patients

R Labrosse, S Barmettler, B Derfalvi, A Blincoe… - Journal of Allergy and …, 2021 - Elsevier
Background Rituximab is a B-cell depleting agent used in B-cell malignancies and
autoimmune diseases. A subset of adult patients may develop prolonged and symptomatic …