The zinc-dependent mammalian histone deacetylase (HDAC) family comprises 11 enzymes,
which have specific and critical functions in development and tissue homeostasis. Mounting …

The population-based association between low vitamin D status and increased cancer risk
can be inconsistent, but it is now generally accepted. These relationships link low serum …

Tumor–stromal communications impact tumorigenesis in ways that are incompletely
understood. Here, we show that glioma-associated human mesenchymal stem cells (GA …

Activated choline metabolism is a hallmark of carcinogenesis and tumor progression, which
leads to elevated levels of phosphocholine and glycerophosphocholine in all types of …

Abstract β-catenin is widely regarded as the primary transducer of canonical WNT signals to
the nucleus. In most vertebrates, there are eight additional catenins that are structurally …

Leukemia is a heterogeneous group of hematological malignancies distinguished by
differentiation blockage and uncontrolled proliferation of myeloid or lymphoid progenitor …

Genetic aberration including mutation in oncogenes and tumor suppressor genes transforms
normal cells into tumor cells. Epigenetic modifications work concertedly with genetic factors …

Vitamin D and calcium are well-established regulators of keratinocyte proliferation and
differentiation. Therefore, it was not a great surprise that deletion of the vitamin D receptor …

Vitamin D3 is biologically inert. To become active, it requires two successive hydroxylation
steps catalyzed by two cytochrome P450 enzymes, first to synthesize the pro-hormone 25 …

IKAROS is a transcription factor forming homo-and heterodimers and regulating lymphocyte
development and function. Germline mutations affecting the IKAROS N-terminal DNA …