BDNF signaling in context: From synaptic regulation to psychiatric disorders

CS Wang, ET Kavalali, LM Monteggia - Cell, 2022 - cell.com
Brain-derived neurotrophic factor (BDNF) is a neuropeptide that plays numerous important
roles in synaptic development and plasticity. While its importance in fundamental physiology …

Brain-derived neurotrophic factor in brain disorders: focus on neuroinflammation

B Lima Giacobbo, J Doorduin, HC Klein… - Molecular …, 2019 - Springer
Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in the
healthy and diseased brain. As a result, there is a large body of evidence that associates …

Neurobiology of BDNF in fear memory, sensitivity to stress, and stress-related disorders

M Notaras, M van den Buuse - Molecular psychiatry, 2020 - nature.com
Brain-derived neurotrophic factor (BDNF) is widely accepted for its involvement in resilience
and antidepressant drug action, is a common genetic locus of risk for mental illnesses, and …

Neuropharmacological modulation of N-methyl-D-aspartate, noradrenaline and endocannabinoid receptors in fear extinction learning: Synaptic transmission and …

S Battaglia, C Di Fazio, CM Vicario… - International Journal of …, 2023 - mdpi.com
Learning to recognize and respond to potential threats is crucial for survival. Pavlovian
threat conditioning represents a key paradigm for investigating the neurobiological …

BDNF and hippocampal synaptic plasticity

G Leal, CR Bramham, CB Duarte - Vitamins and hormones, 2017 - Elsevier
Brain-derived neurotrophic factor (BDNF) belongs to a family of small secreted proteins that
also include nerve growth factor, neurotrophin 3, and neurotrophin 4. BDNF stands out …

BDNF and synaptic plasticity, cognitive function, and dysfunction

B Lu, G Nagappan, Y Lu - Neurotrophic factors, 2014 - Springer
Among all neurotrophins, brain-derived neurotrophic factor (BDNF) stands out for its high
level of expression in the brain and its potent effects on synapses. It is now widely accepted …

Neurotrophin regulation of neural circuit development and function

H Park, M Poo - Nature Reviews Neuroscience, 2013 - nature.com
Brain-derived neurotrophic factor (BDNF)—a member of a small family of secreted proteins
that includes nerve growth factor, neurotrophin 3 and neurotrophin 4—has emerged as a …

Neurobiology of local and intercellular BDNF signaling

M Sasi, B Vignoli, M Canossa, R Blum - Pflügers Archiv-European Journal …, 2017 - Springer
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of secreted
proteins. Signaling cascades induced by BDNF and its receptor, the receptor tyrosine kinase …

Endocrine crosstalk between skeletal muscle and the brain

J Delezie, C Handschin - Frontiers in neurology, 2018 - frontiersin.org
Skeletal muscle is an essential regulator of energy homeostasis and a potent coordinator of
exercise-induced adaptations in other organs including the liver, fat or the brain. Skeletal …

Brain-derived neurotrophic factor and neuropsychiatric disorders

AE Autry, LM Monteggia, LC Daws - Pharmacological reviews, 2012 - Elsevier
Brain derived neurotrophic factor (BDNF) is the most prevalent growth factor in the central
nervous system (CNS). It is essential for the development of the CNS and for neuronal …