Osteoporosis is a common disease in the elderly population. The progress of this disease
results in the reduction of bone mass and can increase the incidence of fractures. Drugs …

Geranylgeranyl diphosphate synthase (GGDPS), an enzyme in the isoprenoid biosynthesis
pathway, is responsible for the production of geranylgeranyl pyrophosphate (GGPP). GGPP …

Abstract The bisphosphonates ((HO) 2 P (O) CR 1 R 2 P (O)(OH) 2, BPs) were first shown to
inhibit bone resorption in the 1960s, but it was not until 30 years later that a detailed …

Bisphosphonate drugs (eg, Fosamax and Zometa) are thought to act primarily by inhibiting
farnesyl diphosphate synthase (FPPS), resulting in decreased prenylation of small GTPases …

Considerable effort has focused on the development of selective protein farnesyl transferase
(FTase) and protein geranylgeranyl transferase (GGTase) inhibitors as cancer …

Dysregulation of isoprenoid biosynthesis is implicated in numerous biochemical disorders
that play a role in the onset and/or progression of age-related diseases, such as …

The biological activity and natural occurrence of the aminophosphonic acids were described
half a century ago. Since then the chemistry and biology of this class of compounds have …

Background Radiation therapy (RT) has a suboptimal effect in patients with pancreatic
ductal adenocarcinoma (PDAC) due to intrinsic and acquired radioresistance (RR) …

Tumor inflammation, the recruitment of myeloid lineage cells into the tumor
microenvironment, promotes angiogenesis, immunosuppression and metastasis. CD11b+ …

We report the X-ray structures of several bisphosphonate inhibitors of geranylgeranyl
diphosphate synthase, a target for anticancer drugs. Bisphosphonates containing …