After more than 20 years of cyclosporine use its nephrotoxicity remains a significant clinical
problem. Cyclosporine-induced renal injury has been described in solid organs recipients …

Cyclosporine and tacrolimus reduce allograft rejection, improve allograft half-life and patient
survival. Ironically, the nephrotoxicity of these agents may adversely affect allograft survival …

We found that peroxisome proliferator-activated receptor-γ (PPARγ) mRNA was reduced by
77% in glomeruli of diabetic mice. Because mesangial cells play an important role in …

Chronic inflammation and increased oxidative stress (OS) play an important role in diabetic
nephropathy progression. Herein, we show that mesangial cells from streptozotocin-induced …

Ochratoxin A (OTA) is the most common contaminant in food and feed, which causes
nephrotoxicity. Studies revealed that a low level of OTA contamination could also cause …

We found that ROP Os/+(Os/+) mice had diffuse glomerulosclerosis and glomerular
hypertrophy and that their mesangial cells (the vascular smooth muscle cells of the …

The aim of this study was to investigate whether apoptosis contributes to nephrotoxicity
caused by amphotericin B (AmB). By detecting apoptosis-specific DNA fragmentation, it is …

Alport syndrome refers to a hereditary disorder characterized by progressive renal disease
and a multilaminar appearance to the glomerular basement membrane (GBM). In a small …

The development and progression of glomerulosclerosis (GS) is determined by the genetic
background. The incidence of end-stage renal disease is increased in postmenopausal …

Background: Cyanate formed spontaneously from urea carbamoylates non-protonated
amino groups of protein, irreversibly altering function, charge and structure. Carbamoylated …