Almost all human diseases are strongly associated with inflammation, and a deep
understanding of the exact mechanism is helpful for treatment. The NLRP3 inflammasome …

The prevalence of diabetes is growing worldwide with an increasing morbidity and mortality
associated with the development of diabetes complications. Free radical production is a …

Pyroptosis is one special type of lytic programmed cell death, featured in cell swelling,
rupture, secretion of cell contents and remarkable proinflammation effect. In the process of …

Highlights•NLRP3 inflammasome activity plays an important role in inflammatory
responses.•NLRP3 inflammasome is also implicated in diabetic nephropathy (DN) …

Diabetic vascular complications can affect both microvascular and macrovascular. Diabetic
microvascular complications, such as diabetic nephropathy, diabetic retinopathy, diabetic …

The inflammatory response has an important role in the pathophysiology of diabetic
nephropathy that is contributed to by inflammatory mediators such as interleukin‐1 (IL‐1), IL …

With aging, the kidney undergoes inexorable and progressive changes in structural and
functional performance. These aging‐related alterations are more obvious and serious in …

Inflammation contributes to the pathogenesis of several diseases. Fenofibrate, known as a
peroxisome proliferator-activated receptor-α (PPAR-α) agonist, is a classic drug for treating …

Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone
receptor superfamily of ligand-activated transcription factors. Accumulating evidence …

Inflammation is a host protection mechanism that eliminates invasive pathogens from the
body. However, chronic inflammation, which occurs repeatedly and continuously over a long …