Strategies for large-scale targeted metabolomics quantification by liquid chromatography-mass spectrometry

J Zhou, Y Yin - Analyst, 2016 - pubs.rsc.org
Advances in liquid chromatography-mass spectrometry (LC-MS) instruments and analytical
strategies have brought about great progress in targeted metabolomics analysis. This …

The secreted metabolome of Streptomyces chartreusis and implications for bacterial chemistry

CHR Senges, A Al-Dilaimi… - Proceedings of the …, 2018 - National Acad Sciences
Actinomycetes are known for producing diverse secondary metabolites. Combining
genomics with untargeted data-dependent tandem MS and molecular networking, we …

Biomedical applications of ion mobility-enhanced data-independent acquisition-based label-free quantitative proteomics

U Distler, J Kuharev, S Tenzer - Expert review of proteomics, 2014 - Taylor & Francis
Mass spectrometry-based proteomics greatly benefited from recent improvements in
instrument performance and the development of bioinformatics solutions facilitating the high …

In‐depth evaluation of software tools for data‐independent acquisition based label‐free quantification

J Kuharev, P Navarro, U Distler, O Jahn, S Tenzer - Proteomics, 2015 - Wiley Online Library
Label‐free quantification (LFQ) based on data‐independent acquisition workflows currently
experiences increasing popularity. Several software tools have been recently published or …

Assessment of BAK1 activity in different plant receptor-like kinase complexes by quantitative profiling of phosphorylation patterns

Y Wang, Z Li, D Liu, J Xu, X Wei, L Yan, C Yang… - Journal of …, 2014 - Elsevier
Plant receptor-like kinases (RLKs) constitute a large family of receptors coordinating
developmental programs with adaptation to environmental stresses including immune …

N-linked glycosite profiling and use of Skyline as a platform for characterization and relative quantification of glycans in differentiating xylem of Populus trichocarpa

PL Loziuk, ES Hecht, DC Muddiman - Analytical and bioanalytical …, 2017 - Springer
Our greater understanding of the importance of N-linked glycosylation in biological systems
has spawned the field of glycomics and development of analytical tools to address the many …

Accurate quantification of β-hexosaminidase released from laboratory of allergic diseases 2 cells via liquid chromatography tandem mass spectrometry method

Y Lv, J Fu, Q Jia, D Che, Y Lin, S Han, L He - Journal of Chromatography A, 2018 - Elsevier
Abstract β-Hexosaminidase is one of the enzymes that is secreted from mast cells via
antigen-induced degranulation and has frequently been used as an indicator of …

3-Iodothyronamine Affects Thermogenic Substrates' Mobilization in Brown Adipocytes

M Gencarelli, A Laurino, E Landucci, D Buonvicino… - Biology, 2020 - mdpi.com
We investigated the effect of 3-iodothyronamine (T1AM) on thermogenic substrates in brown
adipocytes (BAs). BAs isolated from the stromal fraction of rat brown adipose tissue were …

Stepped collisional energy MSAll: an analytical approach for optimal MS/MS acquisition of complex mixture with diverse physicochemical properties

H Ye, L Wang, L Zhu, D Sun, X Luo… - Journal of Mass …, 2016 - Wiley Online Library
The analysis of complex mixtures is becoming increasingly important in various fields, such
as nutrition, medicinal plants and metabolomics. The components contained in such …

A high-resolution mass spectrometry-based quantitative metabolomic workflow highlights defects in 5-fluorouracil metabolism in cancer cells with acquired …

S Shahi, CS Ang, S Mathivanan - Biology, 2020 - mdpi.com
Currently, 5-fluorouracil (5-FU)-based combination chemotherapy is the mainstay in the
treatment of metastatic colorectal cancer (CRC), which benefits approximately 50% of the …