Bioinformatic tools for microRNA dissection

MM Akhtar, L Micolucci, MS Islam, F Olivieri… - Nucleic acids …, 2016 - academic.oup.com
Recently, microRNAs (miRNAs) have emerged as important elements of gene regulatory
networks. MiRNAs are endogenous single-stranded non-coding RNAs (∼ 22-nt long) that …

Post-transcriptional control of circadian rhythms

S Kojima, DL Shingle, CB Green - Journal of cell science, 2011 - journals.biologists.com
Circadian rhythms exist in most living organisms. The general molecular mechanisms that
are used to generate 24-hour rhythms are conserved among organisms, although the details …

MiR-21 protected human glioblastoma U87MG cells from chemotherapeutic drug temozolomide induced apoptosis by decreasing Bax/Bcl-2 ratio and caspase-3 …

L Shi, J Chen, J Yang, T Pan, S Zhang, Z Wang - Brain research, 2010 - Elsevier
MicroRNAs (miRNAs) are small noncoding RNA molecules that regulate protein expression
by cleaving or repressing the translation of target mRNAs. In mammal animals, their function …

[HTML][HTML] Identification of blood microRNAs associated to Parkinsońs disease

R Margis, R Margis, CRM Rieder - Journal of biotechnology, 2011 - Elsevier
The present study demonstrates that blood samples can be used as a source of miRNA
identification associated to Parkinson's disease (PD). A set of six differentially expressed …

Aberrant microRNA expression in the brains of neurodegenerative diseases: miR‐29a decreased in Alzheimer disease brains targets neurone navigator 3

M Shioya, S Obayashi, H Tabunoki… - Neuropathology and …, 2010 - Wiley Online Library
M. Shioya, S. Obayashi, H. Tabunoki, K. Arima, Y. Saito, T. Ishida and J. Satoh (2010)
Neuropathology and Applied Neurobiology36, 320–330 Aberrant microRNA expression in …

Identifying microRNA targets in different gene regions

W Xu, A San Lucas, Z Wang, Y Liu - BMC bioinformatics, 2014 - Springer
Abstract Background Currently available microRNA (miRNA) target prediction algorithms
require the presence of a conserved seed match to the 5'end of the miRNA and limit the …

Both mature miR-17-5p and passenger strand miR-17-3p target TIMP3 and induce prostate tumor growth and invasion

X Yang, WW Du, H Li, F Liu, A Khorshidi… - Nucleic acids …, 2013 - academic.oup.com
Abstract MicroRNAs (miRNA) precursor (pre-miRNA) molecules can be processed to
release a miRNA/miRNA* duplex. In the canonical model of miRNA biogenesis, one strand …

[HTML][HTML] Expression, regulation and mechanism of action of the miR-17-92 cluster in tumor cells

LL Fang, XH Wang, BF Sun… - International …, 2017 - spandidos-publications.com
MicroRNAs (miRNAs), a class of short, single‑stranded non‑coding RNAs, regulate and
control gene expression in eukaryotes by degrading mRNA at the post‑transcriptional level …

[HTML][HTML] Targeting miRNAs by natural products: A new way for cancer therapy

B Zhang, L Tian, J Xie, G Chen, F Wang - Biomedicine & Pharmacotherapy, 2020 - Elsevier
MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression through
mRNA degradation or translation inhibition. MiRNAs play important roles in a variety of …

Deep-sequencing of endothelial cells exposed to hypoxia reveals the complexity of known and novel microRNAs

C Voellenkle, J Van Rooij, A Guffanti, E Brini… - Rna, 2012 - rnajournal.cshlp.org
In order to understand the role of microRNAs (miRNAs) in vascular physiopathology, we
took advantage of deep-sequencing techniques to accurately and comprehensively profile …