Biochemistry and genetics of von Willebrand factor

JE Sadler - Annual review of biochemistry, 1998 - annualreviews.org
Von Willebrand factor (VWF) is a blood glycoprotein that is required for normal hemostasis,
and deficiency of VWF, or von Willebrand disease (VWD), is the most common inherited …

Adhesion mechanisms in platelet function

ZM Ruggeri, GL Mendolicchio - Circulation research, 2007 - Am Heart Assoc
Platelet adhesion is an essential function in response to vascular injury and is generally
viewed as the first step during which single platelets bind through specific membrane …

Platelet glycoprotein Ibα is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18)

DI Simon, Z Chen, H Xu, CQ Li, J Dong… - The Journal of …, 2000 - rupress.org
The firm adhesion and transplatelet migration of leukocytes on vascular thrombus are both
dependent on the interaction of the leukocyte integrin, Mac-1, and a heretofore unknown …

Cell surface tumor endothelial markers are conserved in mice and humans

EB Carson-Walter, DN Watkins, A Nanda, B Vogelstein… - Cancer research, 2001 - AACR
We recently identified genes encoding tumor endothelial markers (TEM s) that displayed
elevated expression during tumor angiogenesis. From both biological and clinical points of …

Platelet adhesion under flow

ZM Ruggeri - Microcirculation, 2009 - Taylor & Francis
Platelet-adhesive mechanisms play a well-defined role in hemostasis and thrombosis, but
evidence continues to emerge for a relevant contribution to other pathophysiological …

The molecular structure of cell adhesion molecules

C Chothia, EY Jones - Annual review of biochemistry, 1997 - annualreviews.org
Considerable advances have been made in our knowledge of the molecular structure of cell
adhesion molecules, their binding sites, and adhesion complexes. For the cadherins, protein …

Mutations in a novel cochlear gene cause DFNA9, a human nonsyndromic deafness with vestibular dysfunction

NG Robertson, L Lu, S Heller, SN Merchant… - Nature …, 1998 - nature.com
DFNA9 is an autosomal dominant, nonsyndromic, progressive sensorineural hearing loss
with vestibular pathology. Here we report three missense mutations in human COCH …

A novel divalent cation-binding site in the A domain of the β2 integrin CR3 (CD11b/CD18) is essential for ligand binding

M Michishita, V Videm, MA Arnaout - Cell, 1993 - cell.com
A recombinant peptide encoding the CD1 1 b A domain bound% lrP+ with a high affinity.
Other divalent cations, including Mg?+, ZrP+, NP+, Co2+, and Cd*+, but not Ca2+ or Ba2+ …

The copines, a novel class of C2 domain-containing, calciumdependent, phospholipid-binding proteins conserved from Paramecium to humans

CE Creutz, JL Tomsig, SL Snyder, MC Gautier… - Journal of Biological …, 1998 - ASBMB
In an attempt to identify proteins that might underlie membrane trafficking processes in
ciliates, calcium-dependent, phospholipid-binding proteins were isolated from extracts of …

The inter-α-inhibitor family: from structure to regulation

JP SALIER, P ROUET, G RAGUENEZ… - Biochemical …, 1996 - portlandpress.com
Inter-α-inhibitor (IαI) and related molecules, collectively referred to as the IαI family, are a
group of plasma protease inhibitors. They display attractive features such as precursor …