The extracellular matrix (ECM) is an integral component of all organs and plays a pivotal
role in tissue homeostasis and repair. While the ECM was long thought to mostly have …

The actin cytoskeleton and associated motor proteins provide the driving forces for
establishing the astonishing morphological diversity and dynamics of mammalian cells …

During metazoan development, immune surveillance and cancer dissemination, cells
migrate in complex three-dimensional microenvironments,–. These spaces are crowded by …

Eukaryotic cells migrate by coupling the intracellular force of the actin cytoskeleton to the
environment. While force coupling is usually mediated by transmembrane adhesion …

Immune responses rely on the rapid and coordinated migration of leukocytes. Whereas it is
well established that single-cell migration is often guided by gradients of chemokines and …

Migration of leukocytes is essential for the induction, maintenance, and regulation of
immune responses. On their trafficking routes, leukocytes encounter microenvironments of …

Motile cells have developed a variety of migration modes relying on diverse traction-force-
generation mechanisms. Before the behavior of intracellular components could be easily …

When crawling through the body, leukocytes often traverse tissues that are densely packed
with extracellular matrix and other cells, and this raises the question: How do leukocytes …

Immunodeficiency often coincides with hyperactive immune disorders such as autoimmunity,
lymphoproliferation, or atopy, but this coincidence is rarely understood on a molecular level …

Neutrophils (polymorphonuclear cells; PMNs) form a first line of defense against pathogens
and are therefore an important component of the innate immune response. As a result of …