USP7 regulates the ncPRC1 Polycomb axis to stimulate genomic H2AK119ub1 deposition uncoupled from H3K27me3
A Sijm, Y Atlasi, JA van der Knaap… - Science …, 2022 - science.org
Ubiquitin-specific protease 7 (USP7) has been implicated in cancer progression and
neurodevelopment. However, its molecular targets remain poorly characterized. We …
neurodevelopment. However, its molecular targets remain poorly characterized. We …
Lessons from Using Genetically Engineered Mouse Models of MYC-Induced Lymphoma
R Winkler, EM Piskor, C Kosan - Cells, 2022 - mdpi.com
Oncogenic overexpression of MYC leads to the fatal deregulation of signaling pathways,
cellular metabolism, and cell growth. MYC rearrangements are found frequently among non …
cellular metabolism, and cell growth. MYC rearrangements are found frequently among non …
PCGF6 controls murine Tuft cell differentiation via H3K9me2 modification independently of Polycomb repression
Cell fate is determined by specific transcription programs that are essential for tissue
homeostasis and regeneration. The E3-ligases RING1A and B represent the core activity of …
homeostasis and regeneration. The E3-ligases RING1A and B represent the core activity of …
Histone H2A deubiquitinases in the transcriptional programs of development and hematopoiesis: a consolidated analysis
HC Wang, D Langlais, A Nijnik - The International Journal of Biochemistry & …, 2023 - Elsevier
Monoubiquitinated lysine 119 of histone H2A (H2AK119ub) is a highly abundant epigenetic
mark, associated with gene repression and deposited on chromatin by the polycomb …
mark, associated with gene repression and deposited on chromatin by the polycomb …
Assessing the Role of MYSM1 Catalytic Activity in MYC Driven Carcinogenesis
V Plackoska - 2023 - search.proquest.com
Myb-like, SWIRM and MPNs domain 1 (MYSM1) is a nuclear-chromatin binding protein with
deubiquitinase (DUB) catalytic activity. In recently published studies, we demonstrated that …
deubiquitinase (DUB) catalytic activity. In recently published studies, we demonstrated that …