Mesenchymal stem/stromal cells in cancer therapy

T Lan, M Luo, X Wei - Journal of Hematology & Oncology, 2021 - Springer
The multipotent mesenchymal stem/stromal cells (MSCs), initially discovered from bone
marrow in 1976, have been identified in nearly all tissues of human body now. The …

Mesenchymal stem cell perspective: cell biology to clinical progress

MF Pittenger, DE Discher, BM Péault… - NPJ Regenerative …, 2019 - nature.com
The terms MSC and MSCs have become the preferred acronym to describe a cell and a cell
population of multipotential stem/progenitor cells commonly referred to as mesenchymal …

Functional heterogeneity of mesenchymal stem cells from natural niches to culture conditions: implications for further clinical uses

LA Costa, N Eiro, M Fraile, LO Gonzalez, J Saá… - Cellular and Molecular …, 2021 - Springer
Mesenchymal stem cells (MSC) are present in all organs and tissues. Several studies have
shown the therapeutic potential effect of MSC or their derived products. However, the …

Mesenchymal stromal cell secretome: influencing therapeutic potential by cellular pre-conditioning

JR Ferreira, GQ Teixeira, SG Santos… - Frontiers in …, 2018 - frontiersin.org
Mesenchymal stromal cells (MSCs) are self-renewing, culture-expandable adult stem cells
that have been isolated from a variety of tissues, and possess multipotent differentiation …

Skin tissue engineering: wound healing based on stem-cell-based therapeutic strategies

A Nourian Dehkordi, F Mirahmadi Babaheydari… - Stem cell research & …, 2019 - Springer
Normal wound healing is a dynamic and complex multiple phase process involving
coordinated interactions between growth factors, cytokines, chemokines, and various cells …

Mesenchymal stem cell‐based immunomodulation: properties and clinical application

M Wang, Q Yuan, L Xie - Stem cells international, 2018 - Wiley Online Library
Mesenchymal stem cells (MSCs) are multipotent stem cells characterized by self‐renewal,
production of clonal cell populations, and multilineage differentiation. They exist in nearly all …

[PDF][PDF] Mesenchymal stromal cell homing: mechanisms and strategies for improvement

M Ullah, DD Liu, AS Thakor - Iscience, 2019 - cell.com
Mesenchymal stromal cells (MSCs) have been widely investigated for their therapeutic
potential in regenerative medicine, owing to their ability to home damaged tissue and serve …

Apoptosis in mesenchymal stromal cells induces in vivo recipient-mediated immunomodulation

A Galleu, Y Riffo-Vasquez, C Trento, C Lomas… - Science translational …, 2017 - science.org
The immunosuppressive activity of mesenchymal stromal cells (MSCs) is well documented.
However, the therapeutic benefit is completely unpredictable, thus raising concerns about …

Mesenchymal stem cells and immunomodulation: current status and future prospects

F Gao, SM Chiu, DAL Motan, Z Zhang, L Chen… - Cell death & …, 2016 - nature.com
The unique immunomodulatory properties of mesenchymal stem cells (MSCs) make them
an invaluable cell type for the repair of tissue/organ damage caused by chronic inflammation …

Regenerative medicine: Current therapies and future directions

AS Mao, DJ Mooney - … of the National Academy of Sciences, 2015 - National Acad Sciences
Organ and tissue loss through disease and injury motivate the development of therapies that
can regenerate tissues and decrease reliance on transplantations. Regenerative medicine …