Treatment of intervertebral disc degeneration

J Xin, Y Wang, Z Zheng, S Wang, S Na… - Orthopaedic …, 2022 - Wiley Online Library
Intervertebral disc degeneration (IDD) causes a variety of signs and symptoms, such as low
back pain (LBP), intervertebral disc herniation, and spinal stenosis, which contribute to high …

Emerging evidence on noncoding-RNA regulatory machinery in intervertebral disc degeneration: a narrative review

HY Guo, MK Guo, ZY Wan, F Song… - Arthritis Research & …, 2020 - Springer
Intervertebral disc degeneration (IDD) is the most common cause of low-back pain.
Accumulating evidence indicates that the expression profiling of noncoding RNAs (ncRNAs) …

Mesenchymal stem cell-derived exosomal microRNA-136-5p inhibits chondrocyte degeneration in traumatic osteoarthritis by targeting ELF3

X Chen, Y Shi, P Xue, X Ma, J Li, J Zhang - Arthritis research & therapy, 2020 - Springer
Background Emerging evidence suggests that microRNAs (miRs) are associated with the
progression of osteoarthritis (OA). In this study, the role of exosomal miR-136-5p derived …

[HTML][HTML] Icariin protects human nucleus pulposus cells from hydrogen peroxide-induced mitochondria-mediated apoptosis by activating nuclear factor erythroid 2 …

W Hua, S Li, R Luo, X Wu, Y Zhang, Z Liao… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Intervertebral disc degeneration (IVDD) is a well-known cause of lower back pain. Icariin has
been shown to exert a protective effect on human nucleus pulposus (NP) cells and …

Pathogenesis and therapeutic implications of matrix metalloproteinases in intervertebral disc degeneration: A comprehensive review

X Zou, X Zhang, S Han, L Wei, Z Zheng, Y Wang, J Xin… - Biochimie, 2023 - Elsevier
Intervertebral disc (IVD) degeneration (IDD) is a common disorder that affects the spine and
is a major cause of lower back pain (LBP). The extracellular matrix (ECM) is the structural …

The potential mechanisms and application prospects of non-coding RNAs in intervertebral disc degeneration

C Jiang, Z Chen, X Wang, Y Zhang, X Guo… - Frontiers in …, 2022 - frontiersin.org
Low back pain (LBP) is one of the most common musculoskeletal symptoms and severely
affects patient quality of life. The majority of people may suffer from LBP during their life …

Polydatin suppresses nucleus pulposus cell senescence, promotes matrix homeostasis and attenuates intervertebral disc degeneration in rats

J Wang, C Huang, Z Lin, X Pan, J Chen… - Journal of cellular …, 2018 - Wiley Online Library
Intervertebral disc degeneration (IVDD) is one of the major causes of low back pain.
Polydatin (PD) has been shown to exert multiple pharmacological effects on different …

microRNA‐365 attenuated intervertebral disc degeneration through modulating nucleus pulposus cell apoptosis and extracellular matrix degradation by targeting …

C Jiang, Y Liu, W Zhao, Y Yang, Z Ren… - Journal of Cellular …, 2024 - Wiley Online Library
This present study is aimed to investigate the role of microRNA‐365 (miR‐365) in the
development of intervertebral disc degeneration (IDD). Nucleus pulposus (NP) cells were …

The potential role and trend of HIF‑1α in intervertebral disc degeneration: Friend or foe?

Y Li, S Liu, D Pan, B Xu, X Xing… - Molecular …, 2021 - spandidos-publications.com
Lower back pain (LBP) is one of the most common reasons for seeking medical advice in
orthopedic clinics. Increasingly, research has shown that symptomatic intervertebral disc …

The role of miRNA, lncRNA and circRNA in the development of intervertebral disk degeneration

J Jiang, Y Sun, G Xu, H Wang… - Experimental and …, 2021 - spandidos-publications.com
Intervertebral disc degeneration (IVDD) is a degenerative musculoskeletal disorder with
multiple causative factors, such as age, genetics, mechanics and life style. IVDD contributes …