[HTML][HTML] Past, present and future of therapeutic strategies against amyloid-β peptides in Alzheimer's disease: A systematic review

D Jeremic, L Jiménez-Díaz, JD Navarro-López - Ageing research reviews, 2021 - Elsevier
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in ageing,
affecting around 46 million people worldwide but few treatments are currently available. The …

Translating 3D printed pharmaceuticals: From hype to real-world clinical applications

I Seoane-Viaño, SJ Trenfield, AW Basit… - Advanced Drug Delivery …, 2021 - Elsevier
Abstract Three-dimensional (3D) printing is a revolutionary technology that is disrupting
pharmaceutical development by enabling the production of personalised printlets (3D …

Current and future treatments for Alzheimer's disease

KG Yiannopoulou… - Therapeutic advances in …, 2013 - journals.sagepub.com
Alzheimer's dementia (AD) is increasingly being recognized as one of the most important
medical and social problems in older people in industrialized and non-industrialized …

Targeting amyloidogenic processing of APP in Alzheimer's disease

J Zhao, X Liu, W Xia, Y Zhang, C Wang - Frontiers in molecular …, 2020 - frontiersin.org
Alzheimer's disease (AD) is the most common type of senile dementia, characterized by
neurofibrillary tangle and amyloid plaque in brain pathology. Major efforts in AD drug were …

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

R Vassar, PH Kuhn, C Haass… - Journal of …, 2014 - Wiley Online Library
The β‐site APP cleaving enzymes 1 and 2 (BACE 1 and BACE 2) were initially identified as
transmembrane aspartyl proteases cleaving the amyloid precursor protein (APP). BACE 1 is …

Targeting prodromal Alzheimer disease with avagacestat: a randomized clinical trial

V Coric, S Salloway, CH van Dyck, B Dubois… - JAMA …, 2015 - jamanetwork.com
Importance Early identification of Alzheimer disease (AD) is important for clinical
management and affords the opportunity to assess potential disease-modifying agents in …

Secretase inhibitors for the treatment of Alzheimer's disease: Long road ahead

D Kumar, A Ganeshpurkar, D Kumar, G Modi… - European journal of …, 2018 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disease, characterized by progressive loss
of memory which is associated with other cognitive deficits. The two protein structures in the …

Therapeutic strategies targeting amyloid-β in Alzheimer's disease

L Pinheiro, C Faustino - Current Alzheimer Research, 2019 - ingentaconnect.com
Alzheimer's disease (AD) is a neurodegenerative disorder linked to protein misfolding and
aggregation. AD is pathologically characterized by senile plaques formed by extracellular …

Recent advancement in therapeutic strategies for Alzheimer's disease: insights from clinical trials

T Khan, R Waseem, M Shahid, J Ansari… - Ageing Research …, 2023 - Elsevier
Alzheimer's disease (AD) is the most prevalent form of dementia, characterized by the
presence of plaques of amyloid beta and Tau proteins. There is currently no permanent cure …

Plasma amyloid beta measurements-a desired but elusive Alzheimer's disease biomarker

JB Toledo, LM Shaw, JQ Trojanowski - Alzheimer's research & therapy, 2013 - Springer
Cerebrospinal fluid and positron emission tomography biomarkers accurately predict an
underlying Alzheimer's disease (AD) pathology; however, they represent either invasive or …