Aurora kinases are serine/threonine kinases essential for the onset and progression of
mitosis. Aurora members share a similar protein structure and kinase activity, but exhibit …

Survivin (also known as BIRC5) is an evolutionarily conserved eukaryotic protein that is
essential for cell division and can inhibit cell death. Normally it is only expressed in actively …

Molecular mechanistic biology has ushered us into the world of life's building blocks,
revealing their interactions in macromolecular complexes and inspiring strategies for …

The cell cycle is an evolutionarily conserved process necessary for mammalian cell growth
and development. Because cell-cycle aberrations are a hallmark of cancer, this process has …

Successful cell division requires the precise and timely coordination of chromosomal,
cytoskeletal and membrane trafficking events. These processes are regulated by the …

Histone posttranslational modifications are key components of diverse processes that
modulate chromatin structure. These marks function as signals during various chromatin …

Since discovery of the centromere-specific histone H3 variant CENP-A, centromeres have
come to be defined as chromatin structures that establish the assembly site for the complex …

Aurora B, a member of the Aurora family of serine/threonine protein kinases, is a key player
in chromosome segregation. As part of a macromolecular complex known as the …

Survivin, as a member of the inhibitor of apoptosis proteins (IAPs) family, acts as a
suppressor of apoptosis and plays a central role in cell division. Survivin has been …

Large numbers of inhibitors for polo-like kinases and aurora kinases are currently being
evaluated as anticancer drugs. Interest in these drugs is fuelled by the idea that these …