Vascularization is fundamental to the growth and spread of tumor cells to distant sites. As a
consequence, angiogenesis, the sprouting of new blood vessels from existing ones, is a …

Since its inception in 2000, metronomic chemotherapy has undergone major advances as
an antiangiogenic therapy. The discovery of the pro-immune properties of chemotherapy …

Metronomic chemotherapy describes the close, regular administration of chemotherapy
drugs at less-toxic doses over prolonged periods of time. In 2015, the results of randomized …

Osteosarcoma (OS) is the most common primary malignant bone tumour with a peak in
incidence during adolescence. Delayed patient presentation and diagnosis is common with …

Bone cancers are characterised by the development of tumour cells in bone sites,
associated with a dysregulation of their environment. In the last two decades, numerous …

Neuroblastoma (NB) is the most common pediatric tumor malignancy that originates from the
neural crest and accounts for more than 15% of all the childhood deaths from cancer. The …

Purpose Pazopanib, an oral multikinase angiogenesis inhibitor, prolongs progression-free
survival in adults with soft tissue sarcoma (STS). A phase I pharmacokinetic and …

Triggered drug delivery strategies have been shown to enhance drug accumulation at target
diseased sites in comparison to administration of free drug. In particular, many studies have …

Hypoxia (low O 2) is a pathobiological hallmark of solid cancers, resulting from the
imbalance between cellular O 2 consumption and availability. Hypoxic cancer cells (CCs) …

Tumor dormancy is the ability of cancer cells to survive in a non-proliferating state. This
condition can depend on three main mechanisms: cell cycle arrest (quiescence or cell …