Dietary natural products as epigenetic modifiers in aging-associated inflammation and disease
Covering: up to 2020 Chronic, low-grade inflammation is linked to aging and has been
termed “inflammaging”. Inflammaging is considered a key contributor to the development of …
termed “inflammaging”. Inflammaging is considered a key contributor to the development of …
Influences of the gut microbiota on DNA methylation and histone modification
The gut microbiota is a vast ensemble of microorganisms inhabiting the mammalian
gastrointestinal tract that can impact physiologic and pathologic processes. However, our …
gastrointestinal tract that can impact physiologic and pathologic processes. However, our …
Periodontal inflammation recruits distant metastatic breast cancer cells by increasing myeloid-derived suppressor cells
Periodontal diseases can lead to chronic inflammation affecting the integrity of the tooth
supporting tissues. Recently, a striking association has been made between periodontal …
supporting tissues. Recently, a striking association has been made between periodontal …
Premature aging is associated with higher levels of 8‐oxoguanine and increased DNA damage in the Polg mutator mouse
Mitochondrial dysfunction plays an important role in the aging process. However, the
mechanism by which this dysfunction causes aging is not fully understood. The …
mechanism by which this dysfunction causes aging is not fully understood. The …
Stromal epigenetic alterations drive metabolic and neuroendocrine prostate cancer reprogramming
Prostate cancer is an androgen-dependent disease subject to interactions between the
tumor epithelium and its microenvironment. Here, we found that epigenetic changes in …
tumor epithelium and its microenvironment. Here, we found that epigenetic changes in …
Mutual inhibition between HDAC9 and miR-17 regulates osteogenesis of human periodontal ligament stem cells in inflammatory conditions
L Li, W Liu, H Wang, Q Yang, L Zhang, F Jin… - Cell death & disease, 2018 - nature.com
Histone deacetylases (HDAC) plays important roles in the post-translational modifications of
histone cores as well as non-histone targets. Many of them are involved in key inflammatory …
histone cores as well as non-histone targets. Many of them are involved in key inflammatory …
Pramipexole and Lactoferrin ameliorate Cyclophosphamide-Induced haemorrhagic cystitis via targeting Sphk1/S1P/MAPK, TLR-4/NF-κB, and NLRP3/caspase-1/IL-1β …
NAA Baky, AH Al-Najjar, HA Elariny, AS Sallam… - International …, 2022 - Elsevier
Background The use of cyclophosphamide (CP) as a chemotherapeutic agent is limited by
its major complication haemorrhagic cystitis (HC). Finding preventive, safe, and efficient …
its major complication haemorrhagic cystitis (HC). Finding preventive, safe, and efficient …
Genome-protecting compounds as potential geroprotectors
Throughout life, organisms are exposed to various exogenous and endogenous factors that
cause DNA damages and somatic mutations provoking genomic instability. At a young age …
cause DNA damages and somatic mutations provoking genomic instability. At a young age …
Functional interplay between methyltransferases and inflammasomes in inflammatory responses and diseases
YS Yi - International Journal of Molecular Sciences, 2021 - mdpi.com
An inflammasome is an intracellular protein complex that is activated in response to a
pathogenic infection and cellular damage. It triggers inflammatory responses by promoting …
pathogenic infection and cellular damage. It triggers inflammatory responses by promoting …
Antagonizing CD105 and androgen receptor to target stromal-epithelial interactions for clinical benefit
Androgen receptor signaling inhibitors (ARSIs) are standard of care for advanced prostate
cancer (PCa) patients. Eventual resistance to ARSIs can include the expression of androgen …
cancer (PCa) patients. Eventual resistance to ARSIs can include the expression of androgen …