L-Type CaV1.2 Calcium Channels: From In Vitro Findings to In Vivo Function
F Hofmann, V Flockerzi, S Kahl… - Physiological …, 2014 - journals.physiology.org
The L-type Cav1. 2 calcium channel is present throughout the animal kingdom and is
essential for some aspects of CNS function, cardiac and smooth muscle contractility …
essential for some aspects of CNS function, cardiac and smooth muscle contractility …
CACNA1C (Cav1. 2) in the pathophysiology of psychiatric disease
S Bhat, DT Dao, CE Terrillion, M Arad, RJ Smith… - Progress in …, 2012 - Elsevier
One of the most consistent genetic findings to have emerged from bipolar disorder genome
wide association studies (GWAS) is with CACNA1C, a gene that codes for the α1C subunit …
wide association studies (GWAS) is with CACNA1C, a gene that codes for the α1C subunit …
CaV1. 2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism
I Splawski, KW Timothy, LM Sharpe, N Decher… - Cell, 2004 - cell.com
Abstract Ca V 1.2, the cardiac L-type calcium channel, is important for excitation and
contraction of the heart. Its role in other tissues is unclear. Here we present Timothy …
contraction of the heart. Its role in other tissues is unclear. Here we present Timothy …
[图书][B] Ion channels and disease
FM Ashcroft - 1999 - books.google.com
Ion channels are membrane proteins that act as gated pathways for the movement of ions
across cell membranes. They play essential roles in the physiology of all cells. In recent …
across cell membranes. They play essential roles in the physiology of all cells. In recent …
Voltage-gated ion channels and hereditary disease
F Lehmann-Horn, K Jurkat-Rott - Physiological reviews, 1999 - journals.physiology.org
By the introduction of technological advancement in methods of structural analysis,
electronics, and recombinant DNA techniques, research in physiology has become …
electronics, and recombinant DNA techniques, research in physiology has become …
L-type calcium channels: the low down
D Lipscombe, TD Helton, W Xu - Journal of …, 2004 - journals.physiology.org
L-type calcium channels couple membrane depolarization in neurons to numerous
processes including gene expression, synaptic efficacy, and cell survival. To establish the …
processes including gene expression, synaptic efficacy, and cell survival. To establish the …
An L-type calcium-channel gene mutated in incomplete X-linked congenital stationary night blindness
TM Strom, G Nyakatura, E Apfelstedt-Sylla… - Nature …, 1998 - nature.com
The locus for the incomplete form of X-linked congenital stationary night blindness (CSNB2)
maps to a 1.1-Mb region in Xp11. 23 between markers DXS722 and DXS255. We identified …
maps to a 1.1-Mb region in Xp11. 23 between markers DXS722 and DXS255. We identified …
Molecular basis of transient outward potassium current downregulation in human heart failure: a decrease in Kv4. 3 mRNA correlates with a reduction in current …
S Kaab, J Dixon, J Duc, D Ashen, M Nabauer… - Circulation, 1998 - Am Heart Assoc
Background—Despite advances in medical therapy, congestive heart failure remains a
major cause of death in the developed world. A disproportionate number of the deaths of …
major cause of death in the developed world. A disproportionate number of the deaths of …
Cardiac ion channels
▪ Abstract The normal electrophysiologic behavior of the heart is determined by ordered
propagation of excitatory stimuli that result in rapid depolarization and slow repolarization …
propagation of excitatory stimuli that result in rapid depolarization and slow repolarization …
Ca channels in cardiac myocytes: structure and function in Ca influx and intracellular Ca release
DM Bers, E Perez-Reyes - Cardiovascular research, 1999 - academic.oup.com
There are Ca channels in the plasma membrane and also the sarcoplasmic reticulum (SR)
membrane in cardiac myocytes. The relationship between channel structure, associated …
membrane in cardiac myocytes. The relationship between channel structure, associated …