OP-EHEA191011_online 2313..2340 Page 1 Low-density lipoproteins cause atherosclerotic
cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a member of the genus
Betacoronavirus within the family Coronaviridae. It is an enveloped single-stranded positive …

Background A subset of patients with COVID-19 develops a hyperinflammatory syndrome
that has similarities with other hyperinflammatory disorders. However, clinical criteria …

During the last decade the field of cancer immunotherapy has witnessed impressive
progress. Highly effective immunotherapies such as immune checkpoint inhibition, and T …

Background: Chimeric antigen receptors redirect T cells (CAR-T) to target cancer cells.
There are limited data characterizing cardiac toxicity and cardiovascular (CV) events among …

Introduction: Cancer-directed immunotherapies are transforming the landscape in oncology
as new and exciting therapies move from the laboratory to the bedside. Chimeric antigen …

T cells in the immune system protect the human body from infection by pathogens and clear
mutant cells through specific recognition by T cell receptors (TCRs). Cancer immunotherapy …

Anti–programmed cell death protein 1 (PD-1) monoclonal antibodies are being increasingly
tested in patients with advanced lymphoma. Following treatment, many of those patients are …

By late 2018, 2 chimeric antigen receptor T (CAR T) cell products have been approved by
US and European regulatory authorities. Tisagenlecleucel (Kymriah, Novartis) is indicated in …

Chimeric antigen receptor (CAR) T cells are a novel class of anti-cancer therapy in which
autologous or allogeneic T cells are engineered to express a CAR targeting a membrane …