Protein-rich foods, sea foods, and gut microbiota amplify immune responses in chronic diseases and cancers–Targeting PERK as a novel therapeutic strategy for …
The endoplasmic reticulum (ER) is a cellular organelle that is physiologically responsible for
protein folding, calcium homeostasis, and lipid biosynthesis. Pathological stimuli such as …
protein folding, calcium homeostasis, and lipid biosynthesis. Pathological stimuli such as …
Immunosuppressive/anti-inflammatory cytokines directly and indirectly inhibit endothelial dysfunction-a novel mechanism for maintaining vascular function
Endothelial dysfunction is a pathological status of the vascular system, which can be broadly
defined as an imbalance between endothelium-dependent vasoconstriction and …
defined as an imbalance between endothelium-dependent vasoconstriction and …
[HTML][HTML] Homocysteine-methionine cycle is a metabolic sensor system controlling methylation-regulated pathological signaling
Homocysteine-Methionine (HM) cycle produces universal methyl group donor S-
adenosylmethione (SAM), methyltransferase inhibitor S-adenosylhomocysteine (SAH) and …
adenosylmethione (SAM), methyltransferase inhibitor S-adenosylhomocysteine (SAH) and …
Quercetin protects mouse liver against nickel-induced DNA methylation and inflammation associated with the Nrf2/HO-1 and p38/STAT1/NF-κB pathway
CM Liu, JQ Ma, WR Xie, SS Liu, ZJ Feng… - Food and Chemical …, 2015 - Elsevier
Quercetin (QE), a natural flavonoid, has been reported to have many benefits and medicinal
properties. However, its protective effects against nickel (Ni) induced injury in liver have not …
properties. However, its protective effects against nickel (Ni) induced injury in liver have not …
29 m6A‐RNA Methylation (Epitranscriptomic) Regulators Are Regulated in 41 Diseases including Atherosclerosis and Tumors Potentially via ROS Regulation – 102 …
We performed a database mining on 102 transcriptomic datasets for the expressions of 29
m6A‐RNA methylation (epitranscriptomic) regulators (m6A‐RMRs) in 41 diseases and …
m6A‐RNA methylation (epitranscriptomic) regulators (m6A‐RMRs) in 41 diseases and …
Tissue Treg secretomes and transcription factors shared with stem cells contribute to a Treg niche to maintain Treg-ness with 80% innate immune pathways, and …
We used functional-omics angles and examined transcriptomic heterogeneity in CD4+
Foxp3+ regulatory T cells (Treg) from spleen (s-Treg), lymph nodes (LN-Treg), intestine (int …
Foxp3+ regulatory T cells (Treg) from spleen (s-Treg), lymph nodes (LN-Treg), intestine (int …
Epigenetic regulation of endothelial dysfunction and inflammation in pulmonary arterial hypertension
J Hudson, L Farkas - International journal of molecular sciences, 2021 - mdpi.com
Once perceived as a disorder treated by vasodilation, pulmonary artery hypertension (PAH)
has emerged as a pulmonary vascular disease with severe endothelial cell dysfunction. In …
has emerged as a pulmonary vascular disease with severe endothelial cell dysfunction. In …
Lysophospholipids and their receptors serve as conditional DAMPs and DAMP receptors in tissue oxidative and inflammatory injury
Y Shao, G Nanayakkara, J Cheng, R Cueto… - Antioxidants & Redox …, 2018 - liebertpub.com
Abstract Significance: We proposed lysophospholipids (LPLs) and LPL-G-protein-coupled
receptors (GPCRs) as conditional danger-associated molecular patterns (DAMPs) and …
receptors (GPCRs) as conditional danger-associated molecular patterns (DAMPs) and …
Hyperlipidemia may synergize with hypomethylation in establishing trained immunity and promoting inflammation in NASH and NAFLD
We performed a panoramic analysis on both human nonalcoholic steatohepatitis (NASH)
microarray data and microarray/RNA‐seq data from various mouse models of nonalcoholic …
microarray data and microarray/RNA‐seq data from various mouse models of nonalcoholic …
Increased expression of resistin in microRNA-155-deficient white adipose tissues may be a possible driver of metabolically healthy obesity transition to classical …
C Johnson, C Drummer IV, A Virtue, T Gao… - Frontiers in …, 2018 - frontiersin.org
We reported that microRNA-155 (miR-155) deficiency in ApoE-/-mice yields a novel
metabolically healthy obese (MHO) model, which exhibits improved atherosclerosis but …
metabolically healthy obese (MHO) model, which exhibits improved atherosclerosis but …