Lipids play important roles in energy metabolism along with diverse aspects of biological
membrane structure, signaling and other functions. Perturbations of lipid metabolism are …

Numerous physiological functions exhibit substantial circadian oscillations. In the kidneys,
renal plasma flow, the glomerular filtration rate and tubular reabsorption and/or secretion …

Obesity caused by genetic and environmental factors can lead to compromised skeletal
muscle function. Time-restricted feeding (TRF) has been shown to prevent muscle function …

This article reviews the literature on the circadian rhythms of body temperature and whole-
organism metabolism. The two rhythms are first described separately, each description …

Curtailed sleep promotes weight gain and loss of lean mass in humans, although the
underlying molecular mechanisms are poorly understood. We investigated the genomic and …

Circadian clocks coordinate mammalian behavior and physiology enabling organisms to
anticipate 24-hour cycles. Transcription-translation feedback loops are thought to drive …

Emerging evidences show that dysregulation of circadian genes is closely associated with
tumorigenesis. However, whether circadian genes regulate the reprogramming of …

Most organisms adapt to the 24-h cycle of the Earth's rotation by anticipating the time of the
day through light-dark cycles. The internal time-keeping system of the circadian clocks has …

Under normal circadian function, metabolic control is temporally coordinated across tissues
and behaviors with a 24-h period. However, circadian disruption results in negative …

Compensation is a defining principle of a true circadian clock, where its approximately 24-
hour period length is relatively unchanged across environmental conditions. Known …