The skin serves as a window for clinicians to understand, diagnose, and monitor endocrine
disease. Dermatologic manifestations of endocrinopathies contribute significantly to an …

Background Potential benefits of rapamycin or rapalogs for treating people with tuberous
sclerosis complex (TSC) have been shown. Currently everolimus (a rapalog) is only …

There are no approved symptomatic treatments for vascular dementia (VaD). Rapamycin
(RAPA) improves cognitive deficits in Alzheimer's disease rats. To explore whether RAPA …

Congenital limb length discrepancy disorders are frequently associated with a variety of
vascular anomalies and have unique genetic and phenotypic features. Many of these …

Diabetic nephropathy (DN), a leading cause of end‐stage renal disease (ESRD), becomes a
worldwide problem. Ultrastructural changes of the glomerular filtration barrier, especially the …

Background and Objective Pulsed Dye Laser (PDL) is currently the gold standard treatment
for port wine stains (PWS), although the degree of lesion blanching is variable and often …

Abstract Background/Objectives Efficacy of topical sirolimus has recently been described in
lymphatic anomalies but not in other types of vascular anomalies. To our knowledge …

ABSTRACT Background: Skin manifestations of Tuberous Sclerosis Complex (TSC) are
present in more than 90% of patients. Facial angiofibromas (AF) are considered a skin …

One of the most visible and potentially disfiguring cutaneous manifestations of tuberous
sclerosis complex is the development of multiple facial angiofibromas, present in over 80 …

Non-Langerhans cell histiocytosis (non-LCH) is a group of diseases characterized by the
proliferation of histiocytes in tissues that is excluded from the diagnostic criteria for LCH …