Intracellular pathways and mechanisms of colored secondary metabolites in cancer therapy

AS Sevastre, EV Manea, OS Popescu… - International Journal of …, 2022 - mdpi.com
Despite the great advancements made in cancer treatment, there are still many unsatisfied
aspects, such as the wide palette of side effects and the drug resistance. There is an obvious …

Programmed cell death disrupts inflammatory tumor microenvironment (TME) and promotes glioblastoma evolution

T Liang, L Gu, X Kang, J Li, Y Song, Y Wang… - Cell Communication and …, 2024 - Springer
Glioblastoma (GBM) is the most common malignant brain tumor and has a dismal prognosis
even under the current first-line treatment, with a 5-year survival rate less than 7 …

Anti-Cancer Activity of Synthesized 5-Benzyl juglone on Selected Human Cancer Cell Lines

C Wang, Y Hu, Y Sun, S Xiang, J Qian… - Anti-Cancer Agents …, 2024 - ingentaconnect.com
Background: Cancer is a malignant disease that causes millions of deaths each year
worldwide. As one of the cancer therapeutic strategies, chemotherapy is a means to destroy …

Juglone induces ferroptosis in glioblastoma cells by inhibiting the Nrf2-GPX4 axis through the phosphorylation of p38MAPK

F Guo, G Ling, J Qiu, J Li, Y Gan, YY Yu, J Tang, L Mo… - Chinese Medicine, 2024 - Springer
Background Ferroptosis, a non-apoptotic form of cell death induced by accumulation of free
iron ions and lipid peroxidation, its importance for cancer treatment is gradually being …

Comprehensive Characterization of Phytochemical Composition, Membrane Permeability, and Antiproliferative Activity of Juglans nigra Polyphenols

R Osztie, T Czeglédi, S Ross, B Stipsicz… - International Journal of …, 2024 - mdpi.com
The aim of our study was the detailed polyphenol profiling of Juglans nigra and the
characterization of the membrane permeability and antiproliferative properties of its main …

Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches

YL Luo, XY Bai, L Zhang, QQ Hu, N Zhang… - Drug Design …, 2024 - Taylor & Francis
Ferroptosis, a unique form of programmed cell death, is initiated by an excess of iron
accumulation and lipid peroxidation-induced damage. There is a growing body of evidence …

Upregulation of apoptotic genes and downregulation of target genes of Sonic Hedgehog signaling pathway in DAOY medulloblastoma cell line treated with arsenic …

M Ghorbanlou, F Moradi, R Shabani… - Journal of …, 2023 - Taylor & Francis
Sonic hedgehog (SHH) medulloblastoma etiology is associated with the SHH molecular
pathway activation at different levels. We investigated the effect of arsenic trioxide as a …

Juglone in Combination with Temozolomide Shows a Promising Epigenetic Therapeutic Effect on the Glioblastoma Cell Line

AM Barciszewska, A Belter, I Gawrońska… - International Journal of …, 2023 - mdpi.com
Glioblastoma (GBM) is the most common and aggressive primary brain tumor and one of the
human malignancies with the highest mortality. Standard approaches for GBM, including …

[引用][C] 胡桃及其附加产品药理活性和机制研究进展

韩馨馨, 王嘉文, 张辉, 孙志华 - 天然产物研究与开发