Physical exercise (PE) improves physical performance, mental status, general health, and
well-being. It does so by affecting many mechanisms at the cellular and molecular level. PE …

The skeletal muscle is the largest organ in the body, by mass. It is also the regulator of
glucose homeostasis, responsible for 80% of postprandial glucose uptake from the …

Top-down mass spectrometry (MS) analyzes intact proteins at the proteoform level, which
allows researchers to better understand the functions of protein modifications. Recently, top …

Proteomes are complex—much more so than genomes or transcriptomes. Thus, simplifying
their analysis does not simplify the issue. Proteomes are of proteoforms, not canonical …

High-intensity interval training (HIIT) improves cardiorespiratory fitness (VO2max), but its
impact on metabolism remains unclear. We hypothesized that 12-week HIIT increases …

Regular exercise has many favorable effects on human health, which may be mediated in
part by the release of circulating bioactive factors during each bout of exercise. Limited data …

Multiple Sclerosis (MS) is a demyelinating disease of the human central nervous system
having an unconfirmed pathoetiology. Although animal models are used to mimic the …

Several clinical examinations have shown the essential impact of monitoring (de) hydration
(fluid and electrolyte imbalance) in cancer patients. There are multiple risk factors …

Skeletal muscle plays a major role in controlling body mass and metabolism: it is the most
abundant tissue of the body and a major source of humoral factors; in addition, it is primarily …

Exercise is one of the most effective treatments for the diseases of aging. In recent years, a
growing number of researchers have used Drosophila melanogaster to study the broad …