Mesenchymal stem/stromal cell-based therapy: mechanism, systemic safety and biodistribution for precision clinical applications

WZ Zhuang, YH Lin, LJ Su, MS Wu, HY Jeng… - Journal of biomedical …, 2021 - Springer
Mesenchymal stem/stromal cells (MSCs) are a promising resource for cell-based therapy
because of their high immunomodulation ability, tropism towards inflamed and injured …

Characteristics and therapeutic potential of human amnion-derived stem cells

QW Liu, QM Huang, HY Wu, GSL Zuo, HC Gu… - International journal of …, 2021 - mdpi.com
Stem cells including embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs)
and adult stem cells (ASCs) are able to repair/replace damaged or degenerative tissues and …

Molecular mechanisms responsible for anti-inflammatory and immunosuppressive effects of mesenchymal stem cell-derived factors

CR Harrell, MG Jankovic, C Fellabaum… - Tissue engineering and …, 2019 - Springer
Mesenchymal stem cells (MSCs) are self-renewable cells capable for multilineage
differentiation and immunomodulation. MSCs are able to differentiate into all cell types of …

[HTML][HTML] Human pluripotent stem cell-derived ectomesenchymal stromal cells promote more robust functional recovery than umbilical cord-derived mesenchymal …

J Huang, F Yang, Z Ji, J Lin, Z Weng, LL Tsang… - Theranostics, 2022 - ncbi.nlm.nih.gov
Aims: Hypoxic-ischaemic encephalopathy (HIE) is one of the most serious complications in
neonates and infants. Mesenchymal stromal cell (MSC)-based therapy is emerging as a …

Paracrine effects of mesenchymal stem cells in ischemic stroke: Opportunities and challenges

A Asgari Taei, P Khodabakhsh, S Nasoohi… - Molecular …, 2022 - Springer
It is well acknowledged that neuroprotective effects of transplanted mesenchymal stem cells
(MSCs) in ischemic stroke are attributed to their paracrine-mediated actions or bystander …

Protein kinase C-delta inhibition protects blood-brain barrier from sepsis-induced vascular damage

Y Tang, F Soroush, S Sun, E Liverani… - Journal of …, 2018 - Springer
Background Neuroinflammation often develops in sepsis leading to activation of cerebral
endothelium, increased permeability of the blood-brain barrier (BBB), and neutrophil …

Secretome as a Tool to Treat Neurological Conditions: Are We Ready?

AV da Silva, I Serrenho, B Araújo, AM Carvalho… - International Journal of …, 2023 - mdpi.com
Due to their characteristics, mesenchymal stem cells (MSCs) are considered a potential
therapy for brain tissue injury or degeneration. Nevertheless, despite the promising results …

Neuroprotective effects of conditioned medium of mesenchymal stem cells (MSC-CM) as a therapy for ischemic stroke recovery: a systematic review

M Behzadifard, N Aboutaleb, M Dolatshahi… - Neurochemical …, 2023 - Springer
It has been reported that the therapeutic potential of stem cells is mainly mediated by their
paracrine factors. In order to identify the effects of conditioned medium of mesenchymal stem …

Therapeutic potential of human amniotic epithelial cells on injuries and disorders in the central nervous system

H Xu, J Zhang, KS Tsang, H Yang… - Stem cells …, 2019 - Wiley Online Library
Despite recent advances in neurosurgery and pharmaceuticals, contemporary treatments
are ineffective in restoring lost neurological functions in patients with injuries and disorders …

Human umbilical cord-derived mesenchymal stem cells promote repair of neonatal brain injury caused by hypoxia/ischemia in rats

Y Jiao, YT Sun, NF Chen, LN Zhou… - Neural Regeneration …, 2022 - journals.lww.com
Administration of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) is
believed to be an effective method for treating neurodevelopmental disorders. In this study …