Introduction: Research over the past three decades has identified p53 as a multi-functional
transcription factor. p53 influences myriad, highly diverse cellular processes, and represents …

Oncolytic viruses (OVs) are an emerging class of targeted anticancer therapies designed to
selectively infect, replicate in, and lyse malignant cells without causing harm to normal …

Glioblastoma multiforme patients have a poor prognosis due to therapeutic resistance and
tumor relapse. It has been suggested that gliomas are driven by a rare subset of tumor cells …

Introduction Glioblastoma is the most common primary malignant brain tumor, and is
refractory to surgical resection, radiation, and chemotherapy. Human mesenchymal stem …

Glioblastoma multiforme (GBM) is the most common primary malignancy in the brain and
confers a uniformly poor prognosis. Despite decades of research on the topic, limited …

Background Central nervous system tumor (CNST) is one of the most complicated and lethal
forms of human tumors with very limited treatment options. In recent years, growing evidence …

Mesenchymal stem/stromal cells (MSCs) are multipotent cells involved in numerous
physiological events, including organogenesis, the maintenance of tissue homeostasis …

Oncolytic viruses (OVs) harness the hallmarks of tumor cells and cancer-related immune
responses for the lysis of malignant cells, modulation of the tumor microenvironment, and …

Background The current treatment regimen for malignant glioblastoma multiforme (GBM) is
tumor resection followed by chemotherapy and radiation therapy. Despite the proven safety …

Replication conditional oncolytic human adenovirus has long been considered a promising
biological therapeutic to target high-grade gliomas (HGG), a group of essentially lethal …