A better understanding of the molecular mechanisms underlying disease is key for
expediting the development of novel therapeutic interventions. Disease mechanisms are …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Missense mutations may affect proteostasis by destabilizing or over-stabilizing protein
complexes and changing the pathway flux. Predicting the effects of stabilizing mutations on …

Studying viral–host protein–protein interactions can facilitate the discovery of therapies for
viral infection. We use high-throughput yeast two-hybrid experiments and mass spectrometry …

Emergence of new viral agents is driven by evolution of interactions between viral proteins
and host targets. For instance, increased infectivity of SARS-CoV-2 compared to SARS-CoV …

Mitochondrial disorders are monogenic disorders characterized by a defect in oxidative
phosphorylation and caused by pathogenic variants in one of over 340 different genes. The …

Intricate biochemical structures are usually thought to be useful, because natural selection
preserves them from degradation by a constant hail of destructive mutations. Biochemists …

Tetrabromobisphenol A (TBBPA), one of the most common flame retardants, affects
neurodevelopment, disrupts the endocrine system, and increases the possibility of …

Protein–protein interfaces have been attracting great attention owing to their critical roles in
protein–protein interactions and the fact that human disease-related mutations are generally …

Maintaining wild type protein–protein interactions is essential for the normal function of cell
and any mutation that alter their characteristics can cause disease. Therefore, the ability to …