Signal processing in the axon initial segment
MHP Kole, GJ Stuart - Neuron, 2012 - cell.com
The axon initial segment (AIS) is a specialized membrane region in the axon of neurons
where action potentials are initiated. Crucial to the function of the AIS is the presence of …
where action potentials are initiated. Crucial to the function of the AIS is the presence of …
The physiology of the axon initial segment
KJ Bender, LO Trussell - Annual review of neuroscience, 2012 - annualreviews.org
The action potential generally begins in the axon initial segment (AIS), a principle confirmed
by 60 years of research; however, the most recent advances have shown that a very rich …
by 60 years of research; however, the most recent advances have shown that a very rich …
All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins
All-optical electrophysiology—spatially resolved simultaneous optical perturbation and
measurement of membrane voltage—would open new vistas in neuroscience research. We …
measurement of membrane voltage—would open new vistas in neuroscience research. We …
[HTML][HTML] Single action potentials and subthreshold electrical events imaged in neurons with a fluorescent protein voltage probe
Monitoring neuronal electrical activity using fluorescent protein-based voltage sensors has
been limited by small response magnitudes and slow kinetics of existing probes. Here we …
been limited by small response magnitudes and slow kinetics of existing probes. Here we …
Optical recording of action potentials in mammalian neurons using a microbial rhodopsin
JM Kralj, AD Douglass, DR Hochbaum, D Maclaurin… - Nature …, 2012 - nature.com
Reliable optical detection of single action potentials in mammalian neurons has been one of
the longest-standing challenges in neuroscience. Here we achieved this goal by using the …
the longest-standing challenges in neuroscience. Here we achieved this goal by using the …
[HTML][HTML] Genetically targeted optical electrophysiology in intact neural circuits
Nervous systems process information by integrating the electrical activity of neurons in
complex networks. This motivates the long-standing interest in using optical methods to …
complex networks. This motivates the long-standing interest in using optical methods to …
Saltatory conduction along myelinated axons involves a periaxonal nanocircuit
CCH Cohen, MA Popovic, J Klooster, MT Weil… - Cell, 2020 - cell.com
The propagation of electrical impulses along axons is highly accelerated by the myelin
sheath and produces saltating or" jumping" action potentials across internodes, from one …
sheath and produces saltating or" jumping" action potentials across internodes, from one …
Cholinergic and noradrenergic axonal activity contains a behavioral-state signal that is coordinated across the dorsal cortex
L Collins, J Francis, B Emanuel, DA McCormick - Elife, 2023 - elifesciences.org
Fluctuations in brain and behavioral state are supported by broadly projecting
neuromodulatory systems. In this study, we use mesoscale two-photon calcium imaging to …
neuromodulatory systems. In this study, we use mesoscale two-photon calcium imaging to …
Mechanisms of sodium channel clustering and its influence on axonal impulse conduction
SA Freeman, A Desmazières, D Fricker… - Cellular and Molecular …, 2016 - Springer
The efficient propagation of action potentials along nervous fibers is necessary for animals
to interact with the environment with timeliness and precision. Myelination of axons is an …
to interact with the environment with timeliness and precision. Myelination of axons is an …
Recent advances in patterned photostimulation for optogenetics
An important technological revolution is underway in the field of neuroscience as we begin
the 21st century. The combination of optical methods with genetically encoded …
the 21st century. The combination of optical methods with genetically encoded …