Hematopoietic stem cells (HSCs) are the life-long source of all types of blood cells. Their
function is controlled by their direct microenvironment, the HSC niche in the bone marrow …

Extracellular vesicles (EVs) have emerged as important players of cancer initiation and
progression through cell-cell communication. They have been recognized as critical …

Background Platelet-derived extracellular vesicles (EVs) participate, for example, in
haemostasis, immunity and development. Most studies of platelet EVs have targeted …

Longtime considered as inert cellular debris, microvesicles (MVs) have gained tremendous
attention in the past decade. MVs are 100–1000 nm vesicles released into the extracellular …

Exosomes contain a wealth of proteomic information, presenting promising biomarkers for
the noninvasive early diagnosis of diseases, especially cancer. However, it remains a great …

Glanzmann thrombasthenia (GT) is one of the best characterised inherited platelet function
disorders but global platelet proteome has not been determined in these patients. We …

Platelet concentrates are used in clinic for therapy and prophylaxis of conditions associated
with platelet deficiency or malfunction. The characteristics of platelet concentrates gradually …

Glioblastoma (GBM) is the most common and aggressive brain tumor in adults. The purpose
of the present study was to identify GBM cell-selective secreted proteins by analyzing …

Objective: Exosomes are small secreted membrane vesicles formed in the late endocytic
compartments by inward budding. Interest in these extracellular vesicles and their role in …

The tetraspanin Tspan8 supports via associated integrins and proteases tumor progression
and angiogenesis. To shed light on its activities in non-transformed cells, we generated a …