Mass spectrometry-based phosphoproteomics is becoming an essential methodology for the
study of global cellular signaling. Numerous bioinformatics resources are available to …

Background The NaCl cotransporter NCC in the kidney distal convoluted tubule (DCT)
regulates urinary NaCl excretion and BP. Aldosterone increases NaCl reabsorption via NCC …

CSNK2B encodes for casein kinase II subunit beta (CK2β), the regulatory subunit of casein
kinase II (CK2), which is known to mediate diverse cellular pathways. Variants in this gene …

Exosomes, derived from multivesicular bodies (MVBs), contain proteins and genetic
materials from their cell of origin and are secreted from various cells types, including kidney …

Diseases of the glomerular filter of the kidney are a leading cause of end‐stage renal failure.
The kidney filter is localized within the renal glomeruli, small microvascular units that are …

Regulated intracellular proteostasis, controlled in part by proteolysis, is essential in
maintaining the integrity of podocytes and the glomerular filtration barrier of the kidney. We …

Membrane fusion is essential for eukaryotic life, requiring SNARE proteins to zipper up in an
α‐helical bundle to pull two membranes together. Here, we show that vesicle fusion can be …

Almost half of patients receiving lithium salts have nephrogenic diabetes insipidus. Chronic
lithium exposure induces AQP2 downregulation and changes in the cellular composition of …

Diseases of the kidney filtration barrier are a leading cause of ESRD. Most disorders affect
the podocytes, polarized cells with a limited capacity for self-renewal that require tightly …

Motivation: Modern proteomics studies utilize high-throughput mass spectrometers which
can produce data at an astonishing rate. These big mass spectrometry (MS) datasets can …