Our knowledge about the genetics of myelodysplastic syndromes (MDS) and related
myeloid disorders has been dramatically improved during the past decade, in which …

RUNX1 is a member of the core-binding factor family of transcription factors and is
indispensable for the establishment of definitive hematopoiesis in vertebrates. RUNX1 is …

Identifying the causes of human diseases requires deconvolution of abnormal molecular
phenotypes spanning DNA accessibility, gene expression and protein abundance,–. We …

Although much work has focused on the elucidation of somatic alterations that drive the
development of acute leukaemias and other haematopoietic diseases, it has become …

In 2003, an international working group last reported on recommendations for diagnosis,
response assessment, and treatment outcomes in acute myeloid leukemia (AML). Since that …

Familial platelet disorder with predisposition to acute myelogenous leukaemia (FPD/AML,
MIM 601399) is an autosomal dominant disorder characterized by qualitative and …

Abstract FLT3 length mutation (FLT3-LM) is a molecular marker potentially useful for the
characterization of acute myeloid leukemia (AML). To evaluate the distribution of FLT3-LM …

The transcription factor C/EBPα (for CCAAT/enhancer binding protein-α; encoded by the
gene CEBPA) is crucial for the differentiation of granulocytes. Conditional expression of …

Runx3/Pebp2αC null mouse gastric mucosa exhibits hyperplasias due to stimulated
proliferation and suppressed apoptosis in epithelial cells, and the cells are resistant to …

▪ Abstract Human leukemias are typified by acquired recurring chromosomal translocations.
Cloning of these translocation breakpoints has provided important insights into …