Recent developments on the synthesis and bioactivity of ilamycins/rufomycins and cyclomarins, marine cyclopeptides that demonstrate anti-malaria and anti …

U Kazmaier, L Junk - Marine Drugs, 2021 - mdpi.com
Ilamycins/rufomycins and cyclomarins are marine cycloheptapeptides containing unusual
amino acids. Produced by Streptomyces sp., these compounds show potent activity against …

Heterologous biosynthesis as a platform for producing new generation natural products

D Park, G Swayambhu, BA Pfeifer - Current Opinion in Biotechnology, 2020 - Elsevier
Highlights•Natural products include numerous societally valuable compounds.•Medicinally
relevant natural products include many clinical antibiotics.•Escherichia coli is a common …

Efficient Mutasynthesis of “Non-Natural” Antitubercular Ilamycins with Low Cytotoxicity

Y Wang, J He, MS Alam, F Wang, Z Shang… - ACS Synthetic …, 2024 - ACS Publications
Ilamycins are a type of cyclopeptide exhibiting potent antitubercular and cytotoxic activities,
which make them promising leads for antitubercular and antitumor drugs with unique …

Transcriptional regulators of secondary metabolite biosynthesis in Streptomyces

X Pei, Y Lei, H Zhang - World Journal of Microbiology and Biotechnology, 2024 - Springer
In the post-genome era, great progress has been made in metabolic engineering using
recombinant DNA technology to enhance the production of high-value products by …

New natural products of Streptomyces sourced from deep-sea, desert, volcanic, and polar regions from 2009 to 2020

J Ting, P Hong, D Yanwen, Y Xiaohui… - Chinese Journal of …, 2021 - sioc-journal.cn
Streptomyces are important sources of natural products. However, it is more challenging to
discover novel compounds from Streptomyces strains isolated from common environmental …

Combinatorial strategies for production improvement of anti-tuberculosis antibiotics ilamycins E1/E2 from deep sea-derived Streptomyces atratus SCSIO ZH16 Δ ilaR

Y Zhu, G Zheng, X Xin, J Ma, J Ju, F An - Bioresources and Bioprocessing, 2022 - Springer
Ilamycins E1/E2 are novel cyclic heptapeptides from Streptomyces atratus SCSIO ZH16,
which have the MIC value of 9.8 nM against Mycobacterium tuberculosis H37Rv. However …

[PDF][PDF] Combinatorial strategies for production improvement of anti-tuberculosis antibiotics ilamycins E

Y Zhu, G Zheng, X Xin, J Ma… - … https://doi. org …, 2022 - bioresourcesbioprocessing …
Ilamycins E1/E2 are novel cyclic heptapeptides from Streptomyces atratus SCSIO ZH16,
which have the MIC value of 9.8 nM against Mycobacterium tuberculosis H37Rv. However …

[PDF][PDF] 深海, 沙漠, 火山, 极地来源链霉菌新天然产物(2009~ 2020)

江婷, 蒲洪, 段燕文, 颜晓晖, 黄勇 - Chin. J. Org. Chem, 2021 - researchgate.net
摘要链霉菌是天然产物的重要来源, 但从土壤来源等普通生态环境筛选出的链霉菌中发现新
化合物的比例有所降低. 深海, 沙漠, 火山或极地属于极端环境, 从中分离出的链霉菌因其特殊 …

Genetics of Marine Organisms Associated with Human Health

M Herak Bosnar, H Ćetković, M Harcet - Marine drugs, 2020 - mdpi.com
The aim of this special issue was to provide insight into the field of research on genetics and
genomics of marine organisms linked with human health. Marine habitats harbour a large …

[引用][C] 途径特异性调控因子介导的链霉菌来源天然产物的产量提升

熊婉, 段燕文, 颜晓晖, 黄勇 - 生物工程学报, 2021