Principles and methods for transferring polygenic risk scores across global populations
Polygenic risk scores (PRSs) summarize the genetic predisposition of a complex human trait
or disease and may become a valuable tool for advancing precision medicine. However …
or disease and may become a valuable tool for advancing precision medicine. However …
A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease
Identification of individuals at highest risk of coronary artery disease (CAD)—ideally before
onset—remains an important public health need. Prior studies have developed genome …
onset—remains an important public health need. Prior studies have developed genome …
A new method for multiancestry polygenic prediction improves performance across diverse populations
Polygenic risk scores (PRSs) increasingly predict complex traits; however, suboptimal
performance in non-European populations raise concerns about clinical applications and …
performance in non-European populations raise concerns about clinical applications and …
Towards a global view of Parkinson's disease genetics
M Khani, C Cerquera‐Cleves, M Kekenadze… - Annals of …, 2024 - Wiley Online Library
Parkinson's disease (PD) is a global health challenge, yet historically studies of PD have
taken place predominantly in European populations. Recent genetics research conducted in …
taken place predominantly in European populations. Recent genetics research conducted in …
Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations
Polygenic risk scores (PRSs) have improved in predictive performance, but several
challenges remain to be addressed before PRSs can be implemented in the clinic, including …
challenges remain to be addressed before PRSs can be implemented in the clinic, including …
Wrestling with social and behavioral genomics: risks, potential benefits, and ethical responsibility
In this consensus report by a diverse group of academics who conduct and/or are concerned
about social and behavioral genomics (SBG) research, the authors recount the often‐ugly …
about social and behavioral genomics (SBG) research, the authors recount the often‐ugly …
An ensemble penalized regression method for multi-ancestry polygenic risk prediction
Great efforts are being made to develop advanced polygenic risk scores (PRS) to improve
the prediction of complex traits and diseases. However, most existing PRS are primarily …
the prediction of complex traits and diseases. However, most existing PRS are primarily …
Novel methods for multi-ancestry polygenic prediction and their evaluations in 5.1 million individuals of diverse ancestry
Polygenic risk scores are becoming increasingly predictive of complex traits, but their
suboptimal performance in non-European ancestry populations raises questions about their …
suboptimal performance in non-European ancestry populations raises questions about their …
Large language models and rheumatology: a comparative evaluation
V Venerito, D Puttaswamy, F Iannone… - The Lancet …, 2023 - thelancet.com
In recent months various large language models (LLMs) have shown substantial potential
across diverse fields, including medicine. 1 GPT-4 by OpenAI is the most well-known LLM …
across diverse fields, including medicine. 1 GPT-4 by OpenAI is the most well-known LLM …
[PDF][PDF] Polygenic prediction across populations is influenced by ancestry, genetic architecture, and methodology
Polygenic risk scores (PRSs) developed from multi-ancestry genome-wide association
studies (GWASs), PRS multi, hold promise for improving PRS accuracy and generalizability …
studies (GWASs), PRS multi, hold promise for improving PRS accuracy and generalizability …