Calcium signaling and reactive oxygen species in mitochondria
In heart failure, alterations of Na+ and Ca2+ handling, energetic deficit, and oxidative stress
in cardiac myocytes are important pathophysiological hallmarks. Mitochondria are central to …
in cardiac myocytes are important pathophysiological hallmarks. Mitochondria are central to …
Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications
Systolic and diastolic myocardial dysfunction has been demonstrated to be associated with
an activation of the circulating and local renin–angiotensin–aldosterone system (RAAS), and …
an activation of the circulating and local renin–angiotensin–aldosterone system (RAAS), and …
Simulation of the undiseased human cardiac ventricular action potential: model formulation and experimental validation
Cellular electrophysiology experiments, important for understanding cardiac arrhythmia
mechanisms, are usually performed with channels expressed in non myocytes, or with non …
mechanisms, are usually performed with channels expressed in non myocytes, or with non …
Calcium cycling and signaling in cardiac myocytes
DM Bers - Annu. Rev. Physiol., 2008 - annualreviews.org
Calcium (Ca) is a universal intracellular second messenger. In muscle, Ca is best known for
its role in contractile activation. However, in recent years the critical role of Ca in other …
its role in contractile activation. However, in recent years the critical role of Ca in other …
Late sodium current inhibition reverses electromechanical dysfunction in human hypertrophic cardiomyopathy
R Coppini, C Ferrantini, L Yao, P Fan, M Del Lungo… - Circulation, 2013 - Am Heart Assoc
Background—Hypertrophic cardiomyopathy (HCM), the most common mendelian heart
disorder, remains an orphan of disease-specific pharmacological treatment because of the …
disorder, remains an orphan of disease-specific pharmacological treatment because of the …
Crosstalk between calcium and ROS in pathophysiological conditions
S Feno, G Butera, D Vecellio Reane… - Oxidative medicine …, 2019 - Wiley Online Library
Calcium ions are highly versatile intracellular signals that regulate many cellular processes.
The key to achieving this pleiotropic role is the spatiotemporal control of calcium …
The key to achieving this pleiotropic role is the spatiotemporal control of calcium …
Mitochondrial reactive oxygen species production and elimination
A Nickel, M Kohlhaas, C Maack - Journal of molecular and cellular …, 2014 - Elsevier
Reactive oxygen species (ROS) play an important role in cardiovascular diseases, and one
important source for ROS are mitochondria. Emission of ROS from mitochondria is the net …
important source for ROS are mitochondria. Emission of ROS from mitochondria is the net …
Cardiac sarcoplasmic reticulum calcium leak: basis and roles in cardiac dysfunction
DM Bers - Annual review of physiology, 2014 - annualreviews.org
Synchronized SR calcium (Ca) release is critical to normal cardiac myocyte excitation-
contraction coupling, and ideally this release shuts off completely between heartbeats …
contraction coupling, and ideally this release shuts off completely between heartbeats …
A novel computational model of the human ventricular action potential and Ca transient
RESULTS. In 100 such simulated experiments we found a RMSD of 4.1451. 15 mV
(mean5SD) between estimate V (t) and data, corresponding to a very close resemblance …
(mean5SD) between estimate V (t) and data, corresponding to a very close resemblance …
Cardiomyocyte stiffness in diastolic heart failure
Background—Heart failure with preserved left ventricular (LV) ejection fraction (EF) is
increasingly recognized and usually referred to as diastolic heart failure (DHF). Its …
increasingly recognized and usually referred to as diastolic heart failure (DHF). Its …