Emergence of SARS-CoV-2 Omicron (B. 1.1. 529) variant, salient features, high global health concerns and strategies to counter it amid ongoing COVID-19 pandemic
Since the appearance in the late of December 2019, SARS-CoV-2 is rapidly evolving and
mutating continuously, giving rise to various variants with variable degrees of infectivity and …
mutating continuously, giving rise to various variants with variable degrees of infectivity and …
Defining the risk of SARS-CoV-2 variants on immune protection
The global emergence of many severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) variants jeopardizes the protective antiviral immunity induced after infection or …
CoV-2) variants jeopardizes the protective antiviral immunity induced after infection or …
[HTML][HTML] Boosting with variant-matched or historical mRNA vaccines protects against Omicron infection in mice
B Ying, SM Scheaffer, B Whitener, CY Liang… - Cell, 2022 - cell.com
The large number of spike substitutions in Omicron lineage variants (BA. 1, BA. 1.1., and BA.
2) could jeopardize the efficacy of SARS-CoV-2 vaccines. We evaluated in mice the …
2) could jeopardize the efficacy of SARS-CoV-2 vaccines. We evaluated in mice the …
Sensitivity to vaccines, therapeutic antibodies, and viral entry inhibitors and advances to counter the SARS-CoV-2 Omicron variant
H Zhou, M Møhlenberg, JC Thakor… - Clinical microbiology …, 2022 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) keeps evolving and
mutating into newer variants over time, which gain higher transmissibility, disease severity …
mutating into newer variants over time, which gain higher transmissibility, disease severity …
SARS‐CoV‐2 Omicron and its current known unknowns: A narrative review
TTB Le, T Vasanthakumaran… - Reviews in Medical …, 2023 - Wiley Online Library
The emergence of the SARS‐CoV‐2 Omicron variant (B. 1.1. 529) has created great global
distress. This variant of concern shows multiple sublineages, importantly B. 1.1. 529.1 (BA …
distress. This variant of concern shows multiple sublineages, importantly B. 1.1. 529.1 (BA …
Heterogeneous infectivity and pathogenesis of SARS-CoV-2 variants beta, delta and omicron in transgenic K18-hACE2 and wildtype mice
F Tarrés-Freixas, B Trinité, A Pons-Grífols… - Frontiers in …, 2022 - frontiersin.org
The emerging SARS-CoV-2 variants of concern (VOCs) may display enhanced
transmissibility, more severity and/or immune evasion; however, the pathogenesis of these …
transmissibility, more severity and/or immune evasion; however, the pathogenesis of these …
SARS-CoV-2 Omicron triggers cross-reactive neutralization and Fc effector functions in previously vaccinated, but not unvaccinated, individuals
SI Richardson, VS Madzorera, H Spencer… - Cell Host & Microbe, 2022 - cell.com
Summary The SARS-CoV-2 Omicron variant escapes neutralizing antibodies elicited by
vaccines or infection. However, whether Omicron triggers cross-reactive humoral responses …
vaccines or infection. However, whether Omicron triggers cross-reactive humoral responses …
[HTML][HTML] Boosting with Omicron-matched or historical mRNA vaccines increases neutralizing antibody responses and protection against B. 1.1. 529 infection in mice
B Ying, SM Scheaffer, B Whitener, CY Liang… - BioRxiv, 2022 - ncbi.nlm.nih.gov
Abstract The B. 1.1. 529 Omicron variant jeopardizes vaccines designed with early
pandemic spike antigens. Here, we evaluated in mice the protective activity of the Moderna …
pandemic spike antigens. Here, we evaluated in mice the protective activity of the Moderna …
Hybrid immunity expands the functional humoral footprint of both mRNA and vector-based SARS-CoV-2 vaccines
Despite the successes of current coronavirus disease 2019 (COVID-19) vaccines, waning
immunity, the emergence of variants of concern, and breakthrough infections among …
immunity, the emergence of variants of concern, and breakthrough infections among …
SARS-CoV-2 Omicron symptomatic infections in previously infected or vaccinated South African healthcare workers
We investigated Omicron infections among healthcare workers (HCW) presenting with
symptoms of SARS-CoV-2 infection and evaluated the protective effect of vaccination or …
symptoms of SARS-CoV-2 infection and evaluated the protective effect of vaccination or …