Bacterial sphingomyelinases and phospholipases as virulence factors

M Flores-Díaz, L Monturiol-Gross… - Microbiology and …, 2016 - Am Soc Microbiol
Bacterial sphingomyelinases and phospholipases are a heterogeneous group of esterases
which are usually surface associated or secreted by a wide variety of Gram-positive and …

Evaluation of Pseudomonas aeruginosa pathogenesis and therapeutics in military‐relevant animal infection models

AG Bobrov, D Getnet, B Swierczewski, A Jacobs… - Apmis, 2022 - Wiley Online Library
Modern combat‐related injuries are often associated with acute polytrauma. As a
consequence of severe combat‐related injuries, a dysregulated immune response results in …

Rutin-loaded liquid crystalline nanoparticles attenuate oxidative stress in bronchial epithelial cells: A PCR validation

M Mehta, KR Paudel, SD Shukla… - Future medicinal …, 2021 - Taylor & Francis
Aim: In the present study, the inhibitory potential of rutin-loaded liquid crystalline
nanoparticles (LCNs) on oxidative stress was determined in human bronchial epithelial cells …

Early growth response 1 suppresses macrophage phagocytosis by inhibiting NRF2 activation through upregulation of autophagy during pseudomonas aeruginosa …

Z Pang, Y Xu, Q Zhu - Frontiers in Cellular and Infection Microbiology, 2022 - frontiersin.org
Pseudomonas aeruginosa is an opportunistic pathogen that causes life-threatening
infections in cystic fibrosis patients and immunocompromised individuals. A tightly regulated …

Role of Host and Bacterial Lipids in Pseudomonas aeruginosa Respiratory Infections

P Constantino-Teles, A Jouault, L Touqui… - Frontiers in …, 2022 - frontiersin.org
The opportunistic pathogen Pseudomonas aeruginosa is one of the most common agents of
respiratory infections and has been associated with high morbidity and mortality rates. The …

Dual-Channel/Localization Single-Molecule Fluorescence Probe for Monitoring ATP and HOCl in Early Diagnosis and Therapy of Rheumatoid Arthritis

W Qu, R Tian, B Yang, T Guo, Z Wu, Y Li… - Analytical …, 2024 - ACS Publications
Rheumatoid arthritis (RA), a common chronic inflammatory illness, is still incurable, reducing
the sufferers' quality of life significantly. Adenosine 5′-triphosphate (ATP) and …

Host phospholipid peroxidation fuels ExoU-dependent cell necrosis and supports Pseudomonas aeruginosa-driven pathology

S Bagayoko, SA Leon-Icaza, M Pinilla, A Hessel… - PLoS …, 2021 - journals.plos.org
Regulated cell necrosis supports immune and anti-infectious strategies of the body;
however, dysregulation of these processes drives pathological organ damage …

ExoU Induces Lung Endothelial Cell Damage and Activates Pro-Inflammatory Caspase-1 during Pseudomonas aeruginosa Infection

KS Hardy, AN Tuckey, P Renema, M Patel… - Toxins, 2022 - mdpi.com
The Gram-negative, opportunistic pathogen Pseudomonas aeruginosa utilizes a type III
secretion system to inject exoenzyme effectors into a target host cell. Of the four best-studied …

Co‐opting oxylipin signals in microbial disease

M Niu, NP Keller - Cellular microbiology, 2019 - Wiley Online Library
Oxylipins, or oxygenated lipids, are universal signalling molecules across all kingdoms of
life. These molecules, either produced by microbial pathogens or their mammalian host …

The processes associated with lipid peroxidation in human embryonic lung fibroblasts, treated with polycyclic aromatic hydrocarbons and organic extract from …

P Rossner, H Libalova, T Cervena, K Vrbova… - …, 2019 - academic.oup.com
Polycyclic aromatic hydrocarbons (PAHs) may cause lipid peroxidation via reactive oxygen
species generation. 15-F2t-isoprostane (IsoP), an oxidative stress marker, is formed from …