Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis

Z Chen, A Bozec, A Ramming, G Schett - Nature Reviews …, 2019 - nature.com
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by a failure of
spontaneous resolution of inflammation. Although the pro-inflammatory cytokines and …

Pharmaceutical and medicinal significance of sulfur (SVI)-Containing motifs for drug discovery: A critical review

C Zhao, KP Rakesh, L Ravidar, WY Fang… - European journal of …, 2019 - Elsevier
Sulfur (S VI) based moieties, especially, the sulfonyl or sulfonamide based analogues have
showed a variety of pharmacological properties, and its derivatives propose a high degree …

Modulation of host immunity by helminths: the expanding repertoire of parasite effector molecules

RM Maizels, HH Smits, HJ McSorley - Immunity, 2018 - cell.com
Helminths are extraordinarily successful parasites due to their ability to modulate the host
immune response. They have evolved a spectrum of immunomodulatory molecules that are …

Construction of efficient deep blue aggregation-induced emission luminogen from triphenylethene for nondoped organic light-emitting diodes

W Qin, Z Yang, Y Jiang, JWY Lam, G Liang… - Chemistry of …, 2015 - ACS Publications
Deep blue emitters are crucial for full color displays and organic white lighting. Thanks to the
research efforts by scientists, many efficient light emitters with aggregation-induced emission …

Immunomodulation by helminths: intracellular pathways and extracellular vesicles

A Zakeri, EP Hansen, SD Andersen… - Frontiers in …, 2018 - frontiersin.org
Helminth parasites are masters at manipulating host immune responses, using an array of
sophisticated mechanisms. One of the major mechanisms enabling helminths to establish …

Unraveling the hygiene hypothesis of helminthes and autoimmunity: origins, pathophysiology, and clinical applications

M Versini, PY Jeandel, T Bashi, G Bizzaro, M Blank… - BMC medicine, 2015 - Springer
Abstract Background The Hygiene Hypothesis (HH) attributes the dramatic increase in
autoimmune and allergic diseases observed in recent decades in Western countries to the …

Secretory products of helminth parasites as immunomodulators

W Harnett - Molecular and biochemical parasitology, 2014 - Elsevier
Parasitic helminths release molecules into their environment, which are generally referred to
as excretory-secretory products or ES. ES derived from a wide range of nematodes …

Parasitic nematode immunomodulatory strategies: recent advances and perspectives

D Cooper, I Eleftherianos - Pathogens, 2016 - mdpi.com
More than half of the described species of the phylum Nematoda are considered parasitic,
making them one of the most successful groups of parasites. Nematodes are capable of …

[HTML][HTML] Synthesis, antiproliferative activity and molecular docking studies of novel doubly modified colchicine amides and sulfonamides as anticancer agents

J Krzywik, W Mozga, M Aminpour, J Janczak, E Maj… - Molecules, 2020 - mdpi.com
Colchicine is a well-known compound with strong antiproliferative activity that has had
limited use in chemotherapy because of its toxicity. In order to create more potent anticancer …

Helminth infections decrease host susceptibility to immune-mediated diseases

JV Weinstock, DE Elliott - The Journal of Immunology, 2014 - journals.aai.org
Helminthic infection has become rare in highly industrialized nations. Concurrent with the
decline in helminthic infection has been an increase in the prevalence of inflammatory …