Actionability is an important concept in medicine that does not have a well-accepted
standard definition, nor is there a general consensus on how to establish it. Medical …

Background Many families and individuals do not meet criteria for a known hereditary
cancer syndrome but display unusual clusters of cancers. These families may carry …

The clinical classification of variants may change with new information, however, there is
limited guidance on how often significant changes in variant classification occur. We used …

Accurate classification of genetic variants is crucial for clinical decision-making in hereditary
cancer. In Spain, genetic diagnostic laboratories have traditionally approached this task …

A hereditary component of breast (BC) and colorectal cancer (CRC) has been described in
approximately one-third of these tumor types. BC patients have an increased risk of …

Purpose Branchpoint elements are required for intron removal, and variants at these
elements can result in aberrant splicing. We aimed to assess the value of branchpoint …

Aim To understand the current usage of eviQ Cancer Treatments Online (www. eviQ. org.
au), an Australian, open‐access website providing evidence‐based and consensus‐driven …

Empirical observations at Familial Cancer Centres across Australia have identified many
families with unusual clusters of cancers and/or individuals with multiple primary cancers …