[HTML][HTML] Bacteriophage lambda: Early pioneer and still relevant
SR Casjens, RW Hendrix - Virology, 2015 - Elsevier
Molecular genetic research on bacteriophage lambda carried out during its golden age from
the mid-1950s to mid-1980s was critically important in the attainment of our current …
the mid-1950s to mid-1980s was critically important in the attainment of our current …
Ultrasound-controllable engineered bacteria for cancer immunotherapy
Rapid advances in synthetic biology are driving the development of genetically engineered
microbes as therapeutic agents for a multitude of human diseases, including cancer. The …
microbes as therapeutic agents for a multitude of human diseases, including cancer. The …
Phage lysis‐lysogeny switches and programmed cell death: Danse macabre
Exploration of immune systems in prokaryotes, such as restriction‐modification or CRISPR‐
Cas, shows that both innate and adaptive systems possess programmed cell death (PCD) …
Cas, shows that both innate and adaptive systems possess programmed cell death (PCD) …
Measurement of gene regulation in individual cells reveals rapid switching between promoter states
In vivo mapping of transcription-factor binding to the transcriptional output of the regulated
gene is hindered by probabilistic promoter occupancy, the presence of multiple gene copies …
gene is hindered by probabilistic promoter occupancy, the presence of multiple gene copies …
Integration-dependent bacteriophage immunity provides insights into the evolution of genetic switches
GW Broussard, LM Oldfield, VM Villanueva, BL Lunt… - Molecular cell, 2013 - cell.com
Genetic switches are critical components of developmental circuits. Because temperate
bacteriophages are vastly abundant and greatly diverse, they are rich resources for …
bacteriophages are vastly abundant and greatly diverse, they are rich resources for …
Engineering orthogonal dual transcription factors for multi-input synthetic promoters
Synthetic biology has seen an explosive growth in the capability of engineering artificial
gene circuits from transcription factors (TFs), particularly in bacteria. However, most artificial …
gene circuits from transcription factors (TFs), particularly in bacteria. However, most artificial …
Expanding the toolbox for Synechocystis sp. PCC 6803: validation of replicative vectors and characterization of a novel set of promoters
Cyanobacteria are promising 'low-cost'cell factories since they have minimal nutritional
requirements, high metabolic plasticity and can use sunlight and CO2 as energy and carbon …
requirements, high metabolic plasticity and can use sunlight and CO2 as energy and carbon …
Revisiting bistability in the lysis/lysogeny circuit of bacteriophage lambda
The lysis/lysogeny switch of bacteriophage lambda serves as a paradigm for binary cell fate
decision, long-term maintenance of cellular state and stimulus-triggered switching between …
decision, long-term maintenance of cellular state and stimulus-triggered switching between …
Bistable expression of a toxin-antitoxin system located in a cryptic prophage of Escherichia coli O157: H7
Type II toxin-antitoxin (TA) systems are classically composed of two genes that encode a
toxic protein and a cognate antitoxin protein. Both genes are organized in an operon whose …
toxic protein and a cognate antitoxin protein. Both genes are organized in an operon whose …
Transcription-Factor-Mediated DNA Looping Probed by High-Resolution, Single-Molecule Imaging in Live E. coli Cells
DNA looping mediated by transcription factors plays critical roles in prokaryotic gene
regulation. The “genetic switch” of bacteriophage λ determines whether a prophage stays …
regulation. The “genetic switch” of bacteriophage λ determines whether a prophage stays …