Post-translational modifications of the TAK1-TAB complex
Transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1) is a member of the mitogen-
activated protein kinase kinase kinase (MAPKKK) family that is activated by growth factors …
activated protein kinase kinase kinase (MAPKKK) family that is activated by growth factors …
TAK1, more than just innate immunity
Transforming growth factor β‐activated kinase 1 (TAK1) is a key regulator of the innate
immunity and the proinflammatory signaling pathway. In response to interleukin‐1, tumor …
immunity and the proinflammatory signaling pathway. In response to interleukin‐1, tumor …
Unravelling the genetic basis of schizophrenia and bipolar disorder with GWAS: A systematic review
Objectives To systematically review findings of GWAS in schizophrenia (SZ) and in bipolar
disorder (BD); and to interpret findings, with a focus on identifying independent replications …
disorder (BD); and to interpret findings, with a focus on identifying independent replications …
[HTML][HTML] Structure of the pseudokinase VRK3 reveals a degraded catalytic site, a highly conserved kinase fold, and a putative regulatory binding site
About 10% of all protein kinases are predicted to be enzymatically inactive pseudokinases,
but the structural details of kinase inactivation have remained unclear. We present the first …
but the structural details of kinase inactivation have remained unclear. We present the first …
Multifaceted roles of TAK1 signaling in cancer
H Mukhopadhyay, NY Lee - Oncogene, 2020 - nature.com
Context-specific signaling is a prevalent theme in cancer biology wherein individual
molecules and pathways can have multiple or even opposite effects depending on the tumor …
molecules and pathways can have multiple or even opposite effects depending on the tumor …
The SRY-HMG box gene, SOX4, is a target of gene amplification at chromosome 6p in lung cancer
PP Medina, SD Castillo, S Blanco… - Human molecular …, 2009 - academic.oup.com
The search for oncogenes is becoming increasingly important in cancer genetics because
they are suitable targets for therapeutic intervention. To identify novel oncogenes, activated …
they are suitable targets for therapeutic intervention. To identify novel oncogenes, activated …
VRK2 is involved in the innate antiviral response by promoting mitostress-induced mtDNA release
WR He, LB Cao, YL Yang, D Hua, MM Hu… - Cellular & Molecular …, 2021 - nature.com
Mitochondrial stress (mitostress) triggered by viral infection or mitochondrial dysfunction
causes the release of mitochondrial DNA (mtDNA) into the cytosol and activates the cGAS …
causes the release of mitochondrial DNA (mtDNA) into the cytosol and activates the cGAS …
Increased oxidative stress and anaerobic energy release, but blunted Thr172-AMPKα phosphorylation, in response to sprint exercise in severe acute hypoxia in …
D Morales-Alamo… - Journal of Applied …, 2012 - journals.physiology.org
AMP-activated protein kinase (AMPK) is a major mediator of the exercise response and a
molecular target to improve insulin sensitivity. To determine if the anaerobic component of …
molecular target to improve insulin sensitivity. To determine if the anaerobic component of …
VRK2A is an A-type lamin–dependent nuclear envelope kinase that phosphorylates BAF
KC Birendra, DG May, BV Benson, DI Kim… - Molecular Biology of …, 2017 - Am Soc Cell Biol
The nuclear envelope (NE) is critical for numerous fundamental cellular functions, and
mutations in several NE constituents can lead to a heterogeneous spectrum of diseases. We …
mutations in several NE constituents can lead to a heterogeneous spectrum of diseases. We …
TAK1 signaling is a potential therapeutic target for pathological angiogenesis
Angiogenesis plays a critical role in both physiological responses and disease
pathogenesis. Excessive angiogenesis can promote neoplastic diseases and retinopathies …
pathogenesis. Excessive angiogenesis can promote neoplastic diseases and retinopathies …