Phenotypic and spatial heterogeneity of CD8+ tumour infiltrating lymphocytes
Y Sun, E Yinwang, S Wang, Z Wang, F Wang, Y Xue… - Molecular Cancer, 2024 - Springer
CD8+ T cells are the workhorses executing adaptive anti-tumour response, and targets of
various cancer immunotherapies. Latest advances have unearthed the sheer heterogeneity …
various cancer immunotherapies. Latest advances have unearthed the sheer heterogeneity …
Multi-omics atlas-assisted discovery of transcription factors for selective T cell state programming
Transcription factors (TFs) regulate the differentiation of T cells into diverse states with
distinct functionalities. To precisely program desired T cell states in viral infections and …
distinct functionalities. To precisely program desired T cell states in viral infections and …
Effective anti-tumor immune responses are orchestrated by immune cell partnership network that functions through tissue homeostatic pathways, not direct cytotoxicity
N Koelsch, F Mirshahi, HF Aqbi, M Seneshaw… - …, 2024 - pmc.ncbi.nlm.nih.gov
The liver hosts a diverse array of immune cells that play pivotal roles in both maintaining
tissue homeostasis and responding to disease. However, the precise contributions of these …
tissue homeostasis and responding to disease. However, the precise contributions of these …
Effective anti-tumor immune responses are orchestrated by immune cell partnership network that functions through tissue homeostatic pathways, not direct cytotoxicity
N Koelsch, F Mirshahi, HF Aqbi, M Seneshaw… - bioRxiv, 2024 - biorxiv.org
The liver hosts a diverse array of immune cells that play pivotal roles in both maintaining
tissue homeostasis and responding to disease. However, the precise contributions of these …
tissue homeostasis and responding to disease. However, the precise contributions of these …
Reduced function of the adaptor SH2B3 promotes T1D via altered γc cytokine-regulated, T cell intrinsic immune tolerance
TK Watson, ABI Rosen, T Drow, JA Medjo… - bioRxiv, 2024 - biorxiv.org
Genome-wide association studies have identified SH2B3 as an important non-MHC gene for
islet autoimmunity and type 1 diabetes (T1D). In this study, we found a single SH2B3 …
islet autoimmunity and type 1 diabetes (T1D). In this study, we found a single SH2B3 …
Natural killer cell dysfunction drives keloid pathogenesis
Y Zhao, Q Wei, R Zeng, Y Wang, Y Yang, Y Wang - bioRxiv, 2024 - biorxiv.org
Keloids, characterized by excessive scar tissue resulting from abnormal wound healing, are
primarily driven by hyperproliferative fibroblasts and overproduction of extracellular matrix …
primarily driven by hyperproliferative fibroblasts and overproduction of extracellular matrix …
CD8+ T cell subsets in acute infection and anti-tumor immunity
I Shryki - 2024 - openarchive.ki.se
CD8+ T cells are key immunotherapeutic targets due to their adaptability and functional
diversity. This thesis investigates the utility of the chemokine receptor CX3CR1 in …
diversity. This thesis investigates the utility of the chemokine receptor CX3CR1 in …
[PDF][PDF] Phenotypic and spatial heterogeneity of CD8 tumour infiltrating lymphocytes
Z Ye - 2024 - molecular-cancer.biomedcentral …
CD8+ T cells are the workhorses executing adaptive anti-tumour response, and targets of
various cancer immunotherapies. Latest advances have unearthed the sheer heterogeneity …
various cancer immunotherapies. Latest advances have unearthed the sheer heterogeneity …